BACKGROUND: Experimental evidence suggests that tumor growth beyond a certain size and tumor ability to metastasize depend on the degree to which the tumor can stimulate an angiogenic response. METHODS: Fifteen thyroid specimens of microinvasive follicular carcinoma were examined for vascularization by immunohistochemical stain with antifactor VIII antibodies and compared with an equal number of follicular adenomas. RESULTS: Pleomorphic areas in the histological specimens of follicular carcinomas had a higher rate of vascularization as did areas of tumor adjacent to or penetrating the capsule. These features were not noted in follicular adenomas. CONCLUSIONS: Our findings indicate that vascularity may play a role in extracapsular extension and tumor aggression in follicular thyroid carcinomas.
BACKGROUND: Experimental evidence suggests that tumor growth beyond a certain size and tumor ability to metastasize depend on the degree to which the tumor can stimulate an angiogenic response. METHODS: Fifteen thyroid specimens of microinvasive follicular carcinoma were examined for vascularization by immunohistochemical stain with antifactor VIII antibodies and compared with an equal number of follicular adenomas. RESULTS: Pleomorphic areas in the histological specimens of follicular carcinomas had a higher rate of vascularization as did areas of tumor adjacent to or penetrating the capsule. These features were not noted in follicular adenomas. CONCLUSIONS: Our findings indicate that vascularity may play a role in extracapsular extension and tumor aggression in follicular thyroid carcinomas.
Authors: Benjamin M Kahn; Alfredo Lucas; Rohan G Alur; Maximillian D Wengyn; Gregory W Schwartz; Jinyang Li; Kathryn Sun; H Carlo Maurer; Kenneth P Olive; Robert B Faryabi; Ben Z Stanger Journal: J Clin Invest Date: 2021-01-19 Impact factor: 14.808
Authors: Shilpi Rajoria; Robert Suriano; Andrea L George; Ameet Kamat; Stimson P Schantz; Jan Geliebter; Raj K Tiwari Journal: J Transl Med Date: 2012-05-01 Impact factor: 5.531