Importance of causation for interpreting occupational epidemiology research: a case study of quartz and cancer.

One of the most important roles for occupational epidemiology is to provide a scientific basis for assessing causation. This chapter discusses the criteria for causation considered by the U.S. Surgeon General, the International Agency for Research on Cancer, and others to place the evidence in historical context. As a case study, the criteria for judging the evidence for potential carcinogenicity of silica dust are examined. The importance of communication with workers and management about causal concerns from workplace exposures is also discussed.