OBJECTIVE: Global myocardial uptake of 123I-metaiodobenzylguanidine (MIBG) has been shown to be decreased in diabetic patients with autonomic neuropathy, indicating cardiac sympathetic dysfunction. However, possible differences in myocardial MIBG distribution between NIDDM and IDDM diabetic patients are not known. RESEARCH DESIGN AND METHODS: Regional myocardial distribution of 123I-MIBG was studied in seven male IDDM patients (age 45 +/- 2 years, duration of diabetes 30 +/- 3 years, means +/- SE) and 13 NIDDM patients (8 men, 5 women, age 59 +/- 2 years, duration of diabetes 10 +/- 1 years). A dual-tracer single-photon emission tomography was carried out with 123I-MIBG and 99mTc-methoxyisobutylisonitrrile to asses simultaneously myocardial sympathetic innervation and perfusion at rest. Conventional autonomic nervous function tests, power spectral analysis of heart rate variability, and echocardiography were performed for assessments of autonomic function and cardiac dimensions and function. RESULTS: Autonomic nervous function tests and echocardiography showed similar results in IDDM and NIDDM patients. Despite this, global myocardial MIBG uptake (0.43 +/- 0.04 vs. 0.59 +/- 0.06, P = 0.03) and MIBG heart-to-liver ratio (0.59 +/- 0.03 vs. 0.68 = 0.03, P = 0.05) were lower in NIDDM compared with IDDM patients. Regional distribution of MIBG uptake and regional MIBG/perfusion ratio revealed significantly reduced uptake in NIDDM patients especially in the inferoposterior segments of the left ventricle compared with IDDM patients. Difference in age between NIDDM and IDDM patients did not explain the results. CONCLUSIONS: Reduced myocardial MIBG uptake was found in NIDDM patients compared with the uptake in IDDM patients, particularly involving inferoposterior segments. Regional sympathetic damage not detectable with conventional autonomic function tests is relatively common in NIDDM.
OBJECTIVE: Global myocardial uptake of 123I-metaiodobenzylguanidine (MIBG) has been shown to be decreased in diabeticpatients with autonomic neuropathy, indicating cardiac sympathetic dysfunction. However, possible differences in myocardial MIBG distribution between NIDDM and IDDM diabeticpatients are not known. RESEARCH DESIGN AND METHODS: Regional myocardial distribution of 123I-MIBG was studied in seven male IDDMpatients (age 45 +/- 2 years, duration of diabetes 30 +/- 3 years, means +/- SE) and 13 NIDDMpatients (8 men, 5 women, age 59 +/- 2 years, duration of diabetes 10 +/- 1 years). A dual-tracer single-photon emission tomography was carried out with 123I-MIBG and 99mTc-methoxyisobutylisonitrrile to asses simultaneously myocardial sympathetic innervation and perfusion at rest. Conventional autonomic nervous function tests, power spectral analysis of heart rate variability, and echocardiography were performed for assessments of autonomic function and cardiac dimensions and function. RESULTS: Autonomic nervous function tests and echocardiography showed similar results in IDDM and NIDDMpatients. Despite this, global myocardial MIBG uptake (0.43 +/- 0.04 vs. 0.59 +/- 0.06, P = 0.03) and MIBG heart-to-liver ratio (0.59 +/- 0.03 vs. 0.68 = 0.03, P = 0.05) were lower in NIDDM compared with IDDMpatients. Regional distribution of MIBG uptake and regional MIBG/perfusion ratio revealed significantly reduced uptake in NIDDMpatients especially in the inferoposterior segments of the left ventricle compared with IDDMpatients. Difference in age between NIDDM and IDDMpatients did not explain the results. CONCLUSIONS: Reduced myocardial MIBG uptake was found in NIDDMpatients compared with the uptake in IDDMpatients, particularly involving inferoposterior segments. Regional sympathetic damage not detectable with conventional autonomic function tests is relatively common in NIDDM.
Authors: Arthur J H A Scholte; Joanne D Schuijf; Victoria Delgado; Jurriaan A Kok; Mieke T J Bus; Arie C Maan; Marcel P Stokkel; Antje V Kharagitsingh; Petra Dibbets-Schneider; Ernst E van der Wall; Jeroen J Bax Journal: Eur J Nucl Med Mol Imaging Date: 2010-04-22 Impact factor: 9.236
Authors: Rodica Pop-Busui; Laurel Roberts; Subramaniam Pennathur; Mathias Kretzler; Frank C Brosius; Eva L Feldman Journal: Am J Kidney Dis Date: 2009-12-30 Impact factor: 8.860