Literature DB >> 8886023

The calcium-independent receptor of alpha-latrotoxin is not a neurexin.

V G Krasnoperov1, R Beavis, O G Chepurny, A R Little, A N Plotnikov, A G Petrenko.   

Abstract

alpha-Latrotoxin (alpha-LTx), a vertebrate neurotoxin isolated from Black Widow Spider venom, causes massive spontaneous neurotransmitter release. The molecular mechanism(s) by which the toxin exerts its effect is largely unknown. Here we report identification and purification of a novel membrane receptor with high affinity for alpha-LTx. Unlike neurexin Ia, a previously described high affinity alpha-LTx receptor, this novel protein binds alpha-LTx independently of Ca2+ presence and therefore may be a mediator of the calcium-independent stimulation of neurotransmitter release by alpha-latrotoxin. The major protein component of calcium-independent alpha-LTx receptors is a novel M(r) 120,000 protein which does not belong to the neurexin family. Among several tissues tested, the M(r) 120,000 protein was found only in brain.

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Year:  1996        PMID： 8886023     DOI： 10.1006/bbrc.1996.1598

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  31 in total

1.  From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders.

Authors:  Ariel F Martinez; Maximilian Muenke; Mauricio Arcos-Burgos
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2010-11-12       Impact factor: 3.568

2.  alpha-Latrotoxin alters spontaneous and depolarization-evoked quantal release from rat adrenal chromaffin cells: evidence for multiple modes of action.

Authors:  J Liu; S Misler
Journal:  J Neurosci       Date:  1998-08-15       Impact factor: 6.167

3.  Vesicle exocytosis stimulated by alpha-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+.

Authors:  B A Davletov; F A Meunier; A C Ashton; H Matsushita; W D Hirst; V G Lelianova; G P Wilkin; J O Dolly; Y A Ushkaryov
Journal:  EMBO J       Date:  1998-07-15       Impact factor: 11.598

4.  A Ca2+-independent receptor for alpha-latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms.

Authors:  M A Bittner; V G Krasnoperov; E L Stuenkel; A G Petrenko; R W Holz
Journal:  J Neurosci       Date:  1998-04-15       Impact factor: 6.167

5.  Neurexin is expressed on nerves, but not at nerve terminals, in the electric organ.

Authors:  A B Russell; S S Carlson
Journal:  J Neurosci       Date:  1997-06-15       Impact factor: 6.167

6.  The adhesion GPCR latrophilin - a novel signaling cascade in oriented cell division and anterior-posterior polarity.

Authors:  Jana Winkler; Simone Prömel
Journal:  Worm       Date:  2016-03-30

Review 7.  Adhesion G protein-coupled receptors in nervous system development and disease.

Authors:  Tobias Langenhan; Xianhua Piao; Kelly R Monk
Journal:  Nat Rev Neurosci       Date:  2016-07-28       Impact factor: 34.870

Review 8.  Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology.

Authors:  Henry A Dunn; Cesare Orlandi; Kirill A Martemyanov
Journal:  Pharmacol Rev       Date:  2019-10       Impact factor: 25.468

9.  New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.

Authors:  Ines Liebscher; Brian Ackley; Demet Araç; Donna M Ariestanti; Gabriela Aust; Byoung-il Bae; Bigyan R Bista; James P Bridges; Joseph G Duman; Felix B Engel; Stefanie Giera; André M Goffinet; Randy A Hall; Jörg Hamann; Nicole Hartmann; Hsi-Hsien Lin; Mingyao Liu; Rong Luo; Amit Mogha; Kelly R Monk; Miriam C Peeters; Simone Prömel; Susanne Ressl; Helgi B Schiöth; Séverine M Sigoillot; Helen Song; William S Talbot; Gregory G Tall; James P White; Uwe Wolfrum; Lei Xu; Xianhua Piao
Journal:  Ann N Y Acad Sci       Date:  2014-11-25       Impact factor: 5.691

10.  Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans.

Authors:  Christopher J Mee; Simon R Tomlinson; Pavel V Perestenko; David De Pomerai; Ian R Duce; Peter N R Usherwood; David R Bell
Journal:  Biochem J       Date:  2004-02-15       Impact factor: 3.857
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