| Literature DB >> 8885289 |
T Ohmori1, T Abekawa, T Koyama.
Abstract
Studies on the mechanisms of behavioral and neurochemical effects of amphetamine or methamphetamine (MA) have focused on the dopaminergic system. However, recent reports suggest that the glutamatergic system may be involved in the MA effects. Our laboratory has been conducting a series of experiments to further examine the role of glutamate in both behavioral and neurotoxic effects of MA. These studies include (1) behavioral studies on the effect of N-methyl-D-aspartate (NMDA) antagonists on the development of MA-induced behavioral sensitization, (2) neurochemical studies on the effects of NMDA antagonists on MA-induced neurotoxicity, and (3) in vivo microdialysis studies on the effects of MA on glutamate release. In the present paper, the authors comment on an important role of glutamatergic systems in the behavioral and toxic effects of MA.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8885289 DOI： 10.1016/0197-0186(95)00152-2
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921