Palisaded encapsulated neuroma (solitary circumscribed neuroma) of the oral mucosa.

The objective of this study was to describe the clinical, histologic, and immunohistochemical features of 12 cases of palisaded encapsulated neuromas occurring on oral mucosa. The lesions were found in adults with a mean age of 54 years (median 58 years), and the most common sites of involvement were the palate and the maxillary labial mucosa. On microscopic evaluation the lesions were well circumscribed, and the tumor cells were spindle-shaped with a fascicular and sometimes whorled pattern. The tumor cells were consistently intensely positive for S-100 protein.