BACKGROUND: 9-cis-Retinoic acid (9-cis-RA) is as active as 13-cis-retinoic acid (13-cis-RA) in inhibiting the proliferation of cultured human sebocytes and in reducing the size of sebaceous glands of hamsters. OBJECTIVE: Evaluate the anti-acne effect of 9-cis-RA compared to that of 13-cis-RA in a pilot study. METHODS: Four young male patients with acne were treated in an open study consecutively with 9-cis-RA and 13-cis-RA given at similar doses. RESULTS: No beneficial effects were observed with 9-cis-RA in any of the patients whereas all responded favorably to 13-cis-RA. CONCLUSION: For the two retinoids tested, the anti-acne effect correlates with the sebosuppressive effect in humans.
BACKGROUND:9-cis-Retinoic acid (9-cis-RA) is as active as 13-cis-retinoic acid (13-cis-RA) in inhibiting the proliferation of cultured human sebocytes and in reducing the size of sebaceous glands of hamsters. OBJECTIVE: Evaluate the anti-acne effect of 9-cis-RA compared to that of 13-cis-RA in a pilot study. METHODS: Four young male patients with acne were treated in an open study consecutively with 9-cis-RA and 13-cis-RA given at similar doses. RESULTS: No beneficial effects were observed with 9-cis-RA in any of the patients whereas all responded favorably to 13-cis-RA. CONCLUSION: For the two retinoids tested, the anti-acne effect correlates with the sebosuppressive effect in humans.
Authors: Amal A Mohamed; Alshymaa Hassnine; Amr Elsayed; Mahmoud Montaser; Yasmeen Ismail; Ahmed El-Demery; Eman Sultan; Rania S Abdel Aziz; Eman Eldemiry; Radwa Hagag; Amal A El-Kholy; Eman Salah Journal: Pharmgenomics Pers Med Date: 2021-12-24