Literature DB >> 8883870

The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus.

M Morales1, E Battenberg, L de Lecea, F E Bloom.   

Abstract

We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT3R). Quantitative analysis indicated that more than 90% of 5-HT3R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT3R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT3R, can affect GABA release and suggests the participation of 5-HT3R in the inhibitory regulation of forebrain neurons.

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Year:  1996        PMID： 8883870     DOI： 10.1016/0006-8993(96)00557-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  26 in total

Review 1.  Serotonin and prefrontal cortex function: neurons, networks, and circuits.

Authors:  M Victoria Puig; Allan T Gulledge
Journal:  Mol Neurobiol       Date:  2011-11-11       Impact factor: 5.590

2.  Immunological characterization of 5-HT3 receptor transmembrane topology.

Authors:  Avron D Spier; Sarah C R Lummis
Journal:  J Mol Neurosci       Date:  2002-06       Impact factor: 3.444

3.  Serotonergic modulation of supragranular neurons in rat sensorimotor cortex.

Authors:  R C Foehring; J F M van Brederode; G A Kinney; W J Spain
Journal:  J Neurosci       Date:  2002-09-15       Impact factor: 6.167

Review 4.  Molecular diversity of neocortical GABAergic interneurones.

Authors:  Maria Blatow; Antonio Caputi; Hannah Monyer
Journal:  J Physiol       Date:  2004-11-11       Impact factor: 5.182

5.  Characterization of 5-HT3 receptor mutations identified in schizophrenic patients.

Authors:  Andrew J Thompson; Nora L Sullivan; Sarah C R Lummis
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

6.  Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08).

Authors:  Koilmani Emmanuvel Rajan; Hemant K Singh; Arunagiri Parkavi; Prisila Dulcy Charles
Journal:  Neurochem Res       Date:  2011-07-07       Impact factor: 3.996

Review 7.  The central 5-HT3 receptor in CNS disorders.

Authors:  F E Bloom; M Morales
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

Review 8.  Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission.

Authors:  K D Alex; E A Pehek
Journal:  Pharmacol Ther       Date:  2006-10-17       Impact factor: 12.310

9.  Background activity of rabbit hippocampal neurons in conditions of functional exclusion of structures which regulate the theta rhythm.

Authors:  V F Kichigina; T A Kudina; K I Zenchenko; O S Vinogradova
Journal:  Neurosci Behav Physiol       Date:  1999 Jul-Aug

10.  A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects.

Authors:  M Kondo; Y Koyama; Y Nakamura; S Shimada
Journal:  Mol Psychiatry       Date:  2017-04-25       Impact factor: 15.992
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