Literature DB >> 8883141

Development and applications of the SCID-hu mouse model.

J M McCune1.   

Abstract

The SCID-hu mouse was designed to serve as a preclinical model for the analysis of human physiology and pathophysiology. In distinction to other immunodeficient mouse models, SCID-hu mice are made upon implantation of intact human organ systems rather than dispersed cell populations. Two constructs, the SCID-hu Thy/Liv and the SCID-hu Bone models, have been developed to reproduce the differentiation and function of human hematopoietic progenitor cells within the human thymus and bone marrow microenvironments, respectively. This review focuses on several applications of these models: definition of multilineage and lineage-restricted human hematopoietic progenitor cells and evaluation of HIV disease and its treatment.

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Mesh：

Year:  1996        PMID： 8883141     DOI： 10.1006/smim.1996.0024

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  16 in total

1.  Identification of T cell-signaling pathways that stimulate latent HIV in primary cells.

Authors:  David G Brooks; Philip A Arlen; Lianying Gao; Christina M R Kitchen; Jerome A Zack
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-20       Impact factor: 11.205

Review 2.  New generation humanized mice for virus research: comparative aspects and future prospects.

Authors:  Ramesh Akkina
Journal:  Virology       Date:  2013-01-05       Impact factor: 3.616

3.  Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model.

Authors:  Anjie Zhen; Valerie Rezek; Cindy Youn; Jonathan Rick; Brianna Lam; Nelson Chang; Jerome Zack; Masakazu Kamata; Scott Kitchen
Journal:  J Vis Exp       Date:  2016-07-02       Impact factor: 1.355

4.  Antibacterial effect of human V gamma 2V delta 2 T cells in vivo.

Authors:  L Wang; A Kamath; H Das; L Li; J F Bukowski
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

Review 5.  Human immune responses and potential for vaccine assessment in humanized mice.

Authors:  Ramesh Akkina
Journal:  Curr Opin Immunol       Date:  2013-04-27       Impact factor: 7.486

6.  SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo.

Authors:  J M Strizki; S Xu; N E Wagner; L Wojcik; J Liu; Y Hou; M Endres; A Palani; S Shapiro; J W Clader; W J Greenlee; J R Tagat; S McCombie; K Cox; A B Fawzi; C C Chou; C Pugliese-Sivo; L Davies; M E Moreno; D D Ho; A Trkola; C A Stoddart; J P Moore; G R Reyes; B M Baroudy
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-16       Impact factor: 11.205

7.  IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo.

Authors:  Cheryl A Stoddart; Mary E Keir; Joseph M McCune
Journal:  PLoS Pathog       Date:  2010-02-19       Impact factor: 6.823

8.  Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.

Authors:  L Covassin; S Jangalwe; N Jouvet; J Laning; L Burzenski; L D Shultz; M A Brehm
Journal:  Clin Exp Immunol       Date:  2013-12       Impact factor: 4.330

9.  Microbicide safety/efficacy studies in animals: macaques and small animal models.

Authors:  Ronald S Veazey
Journal:  Curr Opin HIV AIDS       Date:  2008-09       Impact factor: 4.283

Review 10.  The utilization of humanized mouse models for the study of human retroviral infections.

Authors:  Rachel Van Duyne; Caitlin Pedati; Irene Guendel; Lawrence Carpio; Kylene Kehn-Hall; Mohammed Saifuddin; Fatah Kashanchi
Journal:  Retrovirology       Date:  2009-08-12       Impact factor: 4.602
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