Literature DB >> 8882438

Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia.

L K Ho1, M J Don, H C Chen, S F Yeh, J M Chen.   

Abstract

The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells. Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.

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Year:  1996        PMID： 8882438     DOI： 10.1021/np960200h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Synthesis of novel and diverse naphtho[1,2-b]furans by phosphine-catalyzed [3+2] annulation of activated 1,4-naphthoquinones and acetylenecarboxylates.

Authors:  Likai Xia; Krishna Bahadur Somai Magar; Yong Rok Lee
Journal:  Mol Divers       Date:  2014-10-01       Impact factor: 2.943

Review 2.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

Review 3.  Anti-hepatitis B activities of Myanmar medicinal plants: a narrative review of current evidence.

Authors:  Ye Htut Linn; Win Win Ei; Lwin Mon Mon Myint; Khin Maung Lwin
Journal:  Virusdisease       Date:  2021-07-14

4.  An Easy Access to Furan-Fused Polyheterocyclic Systems.

Authors:  Alice Benzi; Lara Bianchi; Gianluca Giorgi; Massimo Maccagno; Giovanni Petrillo; Domenico Spinelli; Cinzia Tavani
Journal:  Molecules       Date:  2022-05-14       Impact factor: 4.927

5.  Investigation of the biosynthetic potential of endophytes in traditional Chinese anticancer herbs.

Authors:  Kristin I Miller; Chen Qing; Daniel Man Yuen Sze; Brett A Neilan
Journal:  PLoS One       Date:  2012-05-22       Impact factor: 3.240

Review 6.  Natural 6-hydroxy-chromanols and -chromenols: structural diversity, biosynthetic pathways and health implications.

Authors:  Marc Birringer; Karsten Siems; Alexander Maxones; Jan Frank; Stefan Lorkowski
Journal:  RSC Adv       Date:  2018-01-26       Impact factor: 4.036

Review 7.  A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications.

Authors:  Min Wen; Qi Chen; Wang Chen; Jing Yang; Xiaogang Zhou; Chunxiang Zhang; Anguo Wu; Jia Lai; Jianping Chen; Qibing Mei; Shuo Yang; Cai Lan; Jianming Wu; Feihong Huang; Long Wang
Journal:  Front Pharmacol       Date:  2022-09-09       Impact factor: 5.988

8.  Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives.

Authors:  Han Luo; Yong-Feng Lv; Hong Zhang; Jiang-Miao Hu; Hong-Mei Li; Shou-Jin Liu
Journal:  Molecules       Date:  2021-05-28       Impact factor: 4.411

9.  Anti-Viral Activity of Indian Plants.

Authors:  B N Dhawan
Journal:  Proc Natl Acad Sci India Sect B Biol Sci       Date:  2012-01-18
  9 in total

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