| Literature DB >> 8882430 |
Y C Kim1, Q M Che, A A Gunatilaka, D G Kingston.
Abstract
Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-beta-D- glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.Entities:
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Year: 1996 PMID： 8882430 DOI： 10.1021/np960125a
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050