Advances of human core temperature minimum and maximal paradoxical sleep propensity by ambient thermal transients.

By using slow thermal transients of reduced amplitude (+/- 3 degrees C (thermoneutrality in humans sleeping nude) during only 1 night (experimental, EX), we have advanced the minimum of rectal temperature (Tre) and the peak of their paradoxical sleep propensity (PPSP) of sleeping subjects. During this EX night Tre minimum was significantly (P = 0.0001) advanced by 143 min versus that observed during baseline night spent at thermoneutrality. The advance of PPSP was objectivated by the more rapid cumulation of paradoxical sleep (P = 0.02) during the second half of EX night, i.e. strictly after the occurrence (around 0330 h) of the new Tre minimum, and by the earlier occurrence of its barycentric point (P = 0.04) between 0330 and 0700 h. The involvement of the central thermoregulatory system on phase-shifting mechanisms is discussed.