Literature DB >> 8879558

Cytotoxic trichilin-type limonoids from Melia azedarach.

K Takeya1, Z S Quio, C Hirobe, H Itokawa.   

Abstract

Five new trichilin-type limonoids, named 12-deacetyltrichilin I (1), 1-acetyltrichilin H (2), 3-deacetyltrichilin H (3), 1-acetyl-3-deacetyltrichilin H (4), 1-acetyl-2-deacetyltrichilin H (5), together with four known trichilins, meliatoxin B1 (6), trichilin H (7), trichilin D (8) and 1,12-diacetyltrichilin B (9) were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopic means and their cytotoxic activities against P388 cells in vitro were tested by means of MTT assay.

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Year:  1996        PMID： 8879558     DOI： 10.1016/0968-0896(96)00128-9

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Growth inhibition and apoptosis-induced effect on human cancer cells of toosendanin, a triterpenoid derivative from chinese traditional medicine.

Authors:  Bin Zhang; Zhong-Feng Wang; Mian-Zhi Tang; Yu-Liang Shi
Journal:  Invest New Drugs       Date:  2005-12       Impact factor: 3.850

2.  Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands.

Authors:  Kuniaki Nerome; Taku Ito-Kureha; Tiziana Paganini; Takao Fukuda; Yasuhiro Igarashi; Hiroto Ashitomi; Shinya Ikematsu; Tadashi Yamamoto
Journal:  Am J Cancer Res       Date:  2020-02-01       Impact factor: 6.166

Review 3.  Limonoids From the Genus Melia (Meliaceae): Phytochemistry, Synthesis, Bioactivities, Pharmacokinetics, and Toxicology.

Authors:  Wenxiang Fan; Linhong Fan; Zhengtao Wang; Li Yang
Journal:  Front Pharmacol       Date:  2022-01-24       Impact factor: 5.810

4.  The Toxicity and Anti-cancer Activity of the Hexane Layer of Melia azedarach L. var. japonica Makino's Bark Extract.

Authors:  Hyun Woo Kim; Se Chan Kang
Journal:  Toxicol Res       Date:  2012-03

5.  Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus.

Authors:  Jian-Qiang Zhao; Yan-Ming Wang; Hong-Tao Zhu; Dong Wang; Sheng-Hong Li; Rong-Rong Cheng; Chong-Ren Yang; Yi-Fei Wang; Min Xu; Ying-Jun Zhang
Journal:  Nat Prod Bioprospect       Date:  2014-07-22

6.  Bio-selective hormonal breast cancer cytotoxic and antioxidant potencies of Melia azedarach L. wild type leaves.

Authors:  Martha Ervina; Hadi Poerwono; Retno Widyowati; Katsuyoshi Matsunami
Journal:  Biotechnol Rep (Amst)       Date:  2020-02-17
  6 in total

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