Literature DB >> 8879541

Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines.

A Gazit1, J Chen, H App, G McMahon, P Hirth, I Chen, A Levitzki.   

Abstract

Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.

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Year:  1996        PMID： 8879541     DOI： 10.1016/0968-0896(96)00107-1

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.

Authors:  Cristina M Dorobantu; Christian Harak; Rahel Klein; Lonneke van der Linden; Jeroen R P M Strating; Hilde M van der Schaar; Volker Lohmann; Frank J M van Kuppeveld
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy.

Authors:  Ami Citri; Iris Alroy; Sara Lavi; Chanan Rubin; Wanping Xu; Nicolas Grammatikakis; Cam Patterson; Len Neckers; David W Fry; Yosef Yarden
Journal:  EMBO J       Date:  2002-05-15       Impact factor: 11.598

3.  Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor.

Authors:  I Alroy; L Soussan; R Seger; Y Yarden
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

4.  Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.

Authors:  Zhi Shi; Amit K Tiwari; Suneet Shukla; Robert W Robey; In-Wha Kim; Smitaben Parmar; Susan E Bates; Qiu-Sheng Si; Curtis S Goldblatt; Ioana Abraham; Li-Wu Fu; Suresh V Ambudkar; Zhe-Sheng Chen
Journal:  Biochem Pharmacol       Date:  2008-11-18       Impact factor: 5.858

5.  Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.

Authors:  Andrew S Felts; Sam A Saleh; Uyen Le; Alice L Rodriguez; C David Weaver; P Jeffrey Conn; Craig W Lindsley; Kyle A Emmitte
Journal:  Bioorg Med Chem Lett       Date:  2009-10-09       Impact factor: 2.823

6.  Studies of ligand-induced site-specific phosphorylation of epidermal growth factor receptor.

Authors:  Lin Guo; Carl J Kozlosky; Lowell H Ericsson; Thomas O Daniel; Douglas P Cerretti; Richard S Johnson
Journal:  J Am Soc Mass Spectrom       Date:  2003-09       Impact factor: 3.109

7.  Novel effects of Brefeldin A (BFA) in signaling through the insulin receptor (IR) pathway and regulating FoxO1-mediated transcription.

Authors:  Paulina Wyrozumska; Jason W Ashley; Sasanka Ramanadham; Qinglan Liu; W Timothy Garvey; Elizabeth Sztul
Journal:  Cell Logist       Date:  2014-01-09

8.  EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor.

Authors:  Olga Troitskaya; Diana Novak; Anna Nushtaeva; Maria Savinkova; Mikhail Varlamov; Mikhail Ermakov; Vladimir Richter; Olga Koval
Journal:  Int J Mol Sci       Date:  2021-11-29       Impact factor: 5.923
  8 in total

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