Literature DB >> 8878515

Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts.

J Cichy1, S Rose-John, J Pryjma, J Travis.   

Abstract

In this study the ability of soluble interleukin-6 receptor (sIL-6R) to stimulate interleukin-6 (IL-6) synthesis in human fibroblasts is described. It was found that sIL-6R, in combination with endogenous or exogenous IL-6, markedly upregulated IL-6 synthesis. These data suggest that increased IL-6 production after stimulation by either interleukin-1 or tumor necrosis factor-alpha would result in complex formation with sIL-6R, rapid uptake, and further synthesis of this cytokine. Furthermore, it would explain the decrease in sIL-6R plasma levels observed in patients suffering from sepsis.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8878515     DOI： 10.1006/bbrc.1996.1507

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  Role of interleukin-6 in hemopoietic and non-hemopoietic synergy mediating TLR4-triggered late murine ileus and endotoxic shock.

Authors:  B M Buchholz; R S Chanthaphavong; T R Billiar; A J Bauer
Journal:  Neurogastroenterol Motil       Date:  2012-04-10       Impact factor: 3.598

2.  Sympathetic neurons can produce and respond to interleukin 6.

Authors:  P März; J G Cheng; R A Gadient; P H Patterson; T Stoyan; U Otten; S Rose-John
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

3.  Oncostatin M, leukaemia-inhibitory factor and interleukin 6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived epithelial cells.

Authors:  J Cichy; S Rose-John; J Travis
Journal:  Biochem J       Date:  1998-01-15       Impact factor: 3.857
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.