Literature DB >> 887802

Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats.

R P Robertson, D J Baylink.   

Abstract

Prostaglandin E2 was infused into thoracic aorta of thyroparathyroidectomized (TPTX) and intact rats. Circulating calcium increased significantly in the TPTX group by 30 minutes and reached an increment of 1.5 +/- 0.21 mg/dl (x +/- SE, p less than .001) by 90 minutes. No calcium increments were observed in the intact rats. It is postulated that prior failures to demonstrate hypercalcemia during PGE2 infusion may have been due to calcitonin counterregulation.

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Year:  1977        PMID: 887802     DOI: 10.1016/0090-6980(77)90140-x

Source DB:  PubMed          Journal:  Prostaglandins        ISSN: 0090-6980


  3 in total

Review 1.  The pathophysiology and clinical aspects of hypercalcemic disorders.

Authors:  D B Lee; E T Zawada; C R Kleeman
Journal:  West J Med       Date:  1978-10

2.  Localization of prostaglandin synthetase in chicken epiphyseal cartilage.

Authors:  F K Northington; T D Oglesby; Y Ishikawa; R E Wuthier
Journal:  Calcif Tissue Res       Date:  1978-12-08

3.  Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia.

Authors:  S H Doppelt; D M Slovik; R M Neer; J Nolan; R M Zusman; J T Potts
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

  3 in total

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