Report of a case of primary skeletal muscle lymphoma and review of the literature.

Primary extranodal lymphoma arising from skeletal muscle is rare. We describe a case of primary skeletal muscle lymphoma, diffuse large B-cell type. A review of the literature showed that it mostly involves the extremities, especially the thighs, in the elderly and has an aggressive histology of the B-cell immunophenotype. Different pathogenetic mechanisms for the occurrence of malignant lymphoma in extranodal sites are discussed.