Literature DB >> 8876174

RNA replication by Q beta replicase: a working model.

D Brown1, L Gold.   

Abstract

Two classes of RNA ligands that bound to separate, high affinity nucleic acid binding sites on Q beta replicase were previously identified. RNA ligands to the two sites, referred to as site I and site II, were used to investigate the molecular mechanism of RNA replication employed by the four-subunit replicase. Replication inhibition by site I- and site II-specific ligands defined two subsets of replicatable RNAs. When provided with appropriate 3' ends, ligands to either site served as replication templates. UV crosslinking experiments revealed that site I is associated with the S1 subunit, site II with elongation factor Tu, and polymerization with the viral subunit of the holoenzyme. These results provide the framework for a three site model describing template recognition and product strand initiation by Q beta replicase.

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Year:  1996        PMID： 8876174      PMCID： PMC38096          DOI： 10.1073/pnas.93.21.11558

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Bacterial proteins required for replication of phage Q ribonucleic acid. Pruification and properties of host factor I, a ribonucleic acid-binding protein.

Authors:  M T Franze de Fernandez; W S Hayward; J T August
Journal:  J Biol Chem       Date:  1972-02-10       Impact factor: 5.157

2.  A replicating RNA molecule suitable for a detailed analysis of extracellular evolution and replication.

Authors:  D L Kacian; D R Mills; F R Kramer; S Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

3.  Characterization of the subunits of Q-beta replicase.

Authors:  R Kamen
Journal:  Nature       Date:  1970-11-07       Impact factor: 49.962

4.  Subunit structure of Q-beta replicase.

Authors:  M Kondo; R Gallerani; C Weissmann
Journal:  Nature       Date:  1970-11-07       Impact factor: 49.962

5.  Autocatalytic synthesis of a viral RNA in vitro.

Authors:  I Haruna; S Spiegelman
Journal:  Science       Date:  1965-11-12       Impact factor: 47.728

6.  Selection and characterization of RNAs replicated by Q beta replicase.

Authors:  D Brown; L Gold
Journal:  Biochemistry       Date:  1995-11-14       Impact factor: 3.162

7.  Subunit I of G beta replicase and 30 S ribosomal protein S1 of Escherichia coli. Evidence for the identity of the two proteins.

Authors:  A J Wahba; M J Miller; A Niveleau; T A Landers; G G Carmichael; K Weber; D A Hawley; L I Slobin
Journal:  J Biol Chem       Date:  1974-05-25       Impact factor: 5.157

8.  Bacteriophage Q replicase contains the protein biosynthesis elongation factors EF Tu and EF Ts.

Authors:  T Blumenthal; T A Landers; K Weber
Journal:  Proc Natl Acad Sci U S A       Date:  1972-05       Impact factor: 11.205

9.  RNA ligands to human nerve growth factor.

Authors:  J Binkley; P Allen; D M Brown; L Green; C Tuerk; L Gold
Journal:  Nucleic Acids Res       Date:  1995-08-25       Impact factor: 16.971

10.  Defining a smaller RNA substrate for elongation factor Tu.

Authors:  I A Nazarenko; O C Uhlenbeck
Journal:  Biochemistry       Date:  1995-02-28       Impact factor: 3.162
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  31 in total

1.  CCA initiation boxes without unique promoter elements support in vitro transcription by three viral RNA-dependent RNA polymerases.

Authors:  S Yoshinari; P D Nagy; A E Simon; T W Dreher
Journal:  RNA       Date:  2000-05       Impact factor: 4.942

2.  Autonomous role of 3'-terminal CCCA in directing transcription of RNAs by Qbeta replicase.

Authors:  D M Tretheway; S Yoshinari; T W Dreher
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

3.  A -1 ribosomal frameshift element that requires base pairing across four kilobases suggests a mechanism of regulating ribosome and replicase traffic on a viral RNA.

Authors:  Jennifer K Barry; W Allen Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-30       Impact factor: 11.205

Review 4.  Mathematical modeling of evolution. Solved and open problems.

Authors:  Peter Schuster
Journal:  Theory Biosci       Date:  2010-09-01       Impact factor: 1.919

5.  Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins.

Authors:  Rune T Kidmose; Nikita N Vasiliev; Alexander B Chetverin; Gregers Rom Andersen; Charlotte R Knudsen
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-01       Impact factor: 11.205

6.  The deleterious effect of an insertion sequence removing the last twenty percent of the essential Escherichia coli rpsA gene is due to mRNA destabilization, not protein truncation.

Authors:  Patricia Skorski; Florence Proux; Chainez Cheraiti; Marc Dreyfus; Sylvie Hermann-Le Denmat
Journal:  J Bacteriol       Date:  2007-07-06       Impact factor: 3.490

7.  A long-range interaction in Qbeta RNA that bridges the thousand nucleotides between the M-site and the 3' end is required for replication.

Authors:  J Klovins; V Berzins; J van Duin
Journal:  RNA       Date:  1998-08       Impact factor: 4.942

8.  Minimal template requirements for initiation of minus-strand synthesis in vitro by the RNA-dependent RNA polymerase of turnip yellow mosaic virus.

Authors:  B A Deiman; A K Koenen; P W Verlaan; C W Pleij
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

9.  Mutational analysis of the GDD sequence motif of classical swine fever virus RNA-dependent RNA polymerases.

Authors:  Yujing Wang; Ming Xiao; Jun Chen; Weiqiong Zhang; Jianglan Luo; Kan Bao; Ming Nie; Jiakuan Chen; Bo Li
Journal:  Virus Genes       Date:  2006-08-18       Impact factor: 2.332

10.  A complex RNA motif defined by three discontinuous 5-nucleotide-long strands is essential for Flavivirus RNA replication.

Authors:  Byung-Hak Song; Sang-Im Yun; Yu-Jeong Choi; Jeong-Min Kim; Chan-Hee Lee; Young-Min Lee
Journal:  RNA       Date:  2008-07-30       Impact factor: 4.942
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