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Literature DB >> 8876131

The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors.

Abstract

Herpes simplex virus vectors are being developed for delivery and expression of human genes to the central nervous system, selective destruction of cancer cells, and as carriers for genes encoding antigens that induce protective immunity against infectious agents. Vectors constructed to meet these objectives must differ from wild-type virus with respect to host range, reactivation from latency, and expression of viral genes. The vectors currently being developed are (i) helper free amplicons, (ii) replication defective viruses, and (iii) genetically engineered replication competent viruses with restricted host range. Whereas the former two types of vectors require stable, continuous cell lines expressing viral genes for their replication, the replication competent viruses will replicate on approved primary human cell strains.

Entities: Disease Species

Mesh：

Year: 1996 PMID： 8876131 PMCID： PMC38053 DOI： 10.1073/pnas.93.21.11307

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

40 in total

1. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons.

Authors: J G Stevens; E K Wagner; G B Devi-Rao; M L Cook; L T Feldman
Journal: Science Date: 1987-02-27 Impact factor: 47.728

2. Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

Authors: J L McKnight; T M Kristie; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 1987-10 Impact factor: 11.205

3. The herpes simplex virus origins of DNA synthesis in the S component are each contained in a transcribed open reading frame.

Authors: J Hubenthal-Voss; L Starr; B Roizman
Journal: J Virol Date: 1987-11 Impact factor: 5.103

Review 4. Genetic engineering of novel genomes of large DNA viruses.

Authors: B Roizman; F J Jenkins
Journal: Science Date: 1985-09-20 Impact factor: 47.728

5. The herpes simplex virus amplicon. IV. Efficient expression of a chimeric chicken ovalbumin gene amplified within defective virus genomes.

Authors: A D Kwong; N Frenkel
Journal: Virology Date: 1985-04-30 Impact factor: 3.616

6. The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component.

Authors: J Chou; B Roizman
Journal: J Virol Date: 1986-02 Impact factor: 5.103

7. Regeneration of herpesviruses from molecularly cloned subgenomic fragments.

Authors: M van Zijl; W Quint; J Briaire; T de Rover; A Gielkens; A Berns
Journal: J Virol Date: 1988-06 Impact factor: 5.103

8. Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides.

Authors: G S Read; N Frenkel
Journal: J Virol Date: 1983-05 Impact factor: 5.103

Review 9. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.

Authors: D J McGeoch; M A Dalrymple; A J Davison; A Dolan; M C Frame; D McNab; L J Perry; J E Scott; P Taylor
Journal: J Gen Virol Date: 1988-07 Impact factor: 3.891

10. Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes.

Authors: W Batterson; B Roizman
Journal: J Virol Date: 1983-05 Impact factor: 5.103

70 in total

1. Small dense nuclear bodies are the site of localization of herpes simplex virus 1 U(L)3 and U(L)4 proteins and of ICP22 only when the latter protein is present.

Authors: N S Markovitz; B Roizman
Journal: J Virol Date: 2000-01 Impact factor: 5.103

Review 2. Conditionally replicating herpes vectors for cancer therapy.

Authors: R L Martuza
Journal: J Clin Invest Date: 2000-04 Impact factor: 14.808

3. Functional anatomy of herpes simplex virus 1 overlapping genes encoding infected-cell protein 22 and US1.5 protein.

Authors: W O Ogle; B Roizman
Journal: J Virol Date: 1999-05 Impact factor: 5.103

4. Nuclear translocation and activation of the transcription factor NFAT is blocked by herpes simplex virus infection.

Authors: E S Scott; S Malcomber; P O'Hare
Journal: J Virol Date: 2001-10 Impact factor: 5.103

5. A third-generation herpesvirus is effective against gastroesophageal cancer.

Authors: Joyce Wong; Kaitlyn Kelly; Arjun Mittra; Segundo Jaime Gonzalez; Kyo Young Song; Guy Simpson; Robert Coffin; Yuman Fong
Journal: J Surg Res Date: 2010-04-01 Impact factor: 2.192

6. The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines.

Authors: E L Bearer; P Satpute-Krishnan
Journal: Curr Drug Targets Infect Disord Date: 2002-09