A new mouse mutation causing male sterility and histoincompatibility.

Male sterility and histoincompatibility, mshi, is an autosomal recessive mutation in BALB/cBy mice that causes reduced testis size and sterility in homozygous males. The testes of homozygous mutants are highly disorganized and appear to have a block in the regulation of male germ cell proliferation. No heterozygous effect is detectable. Reproduction is unaffected in females carrying the mutation. The mutation also affects histocompatibility; most homozygous males and females reject sex-matched skin grafts from BALB/cBy mice. We used an intercross between BALB/cBy and CAST/Ei to map the mshi mutation to the proximal end of Chromosome (Chr) 10. The most likely gene order places the mutation between D10Mit80 and D10Mit16, near the interferon gamma receptor locus, Ifgr, which may be a candidate gene for this mutation.