Literature DB >> 8875123

The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.

R W Milne1, R L Nation, A A Somogyi.   

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Year:  1996        PMID: 8875123     DOI: 10.3109/03602539608994011

Source DB:  PubMed          Journal:  Drug Metab Rev        ISSN: 0360-2532            Impact factor:   4.518


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  33 in total

1.  Comparison of the disposition of hepatically-generated morphine-3-glucuronide and morphine-6-glucuronide in isolated perfused liver from the guinea pig.

Authors:  R W Milne; R H Jensen; C Larsen; A M Evans; R L Nation
Journal:  Pharm Res       Date:  1997-08       Impact factor: 4.200

2.  Induction of morphine-6-glucuronide synthesis by heroin self-administration in the rat.

Authors:  Maria Meringolo; Valentina Brusadin; Maria T De Luca; Christian Montanari; Christian L Montanari; Letizia Antonilli; Paolo Nencini; Aldo Badiani
Journal:  Psychopharmacology (Berl)       Date:  2011-10-21       Impact factor: 4.530

3.  Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat.

Authors:  S P Letrent; G M Pollack; K R Brouwer; K L Brouwer
Journal:  Pharm Res       Date:  1998-04       Impact factor: 4.200

4.  Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat.

Authors:  Didier Jourdan; Gisèle Pickering; Fabien Marchand; Jean-Michel Gaulier; Josette Alliot; Alain Eschalier
Journal:  Br J Pharmacol       Date:  2002-11       Impact factor: 8.739

5.  Interspecies scaling for the prediction of drug clearance in children: application of maximum lifespan potential and an empirical correction factor.

Authors:  Iftekhar Mahmood
Journal:  Clin Pharmacokinet       Date:  2010-07       Impact factor: 6.447

6.  Relationship between plasma concentrations of morphine and its metabolites and pain in cancer patients.

Authors:  Tomoya Sakurada; Shinya Takada; Hisae Eguchi; Keishiro Izumi; Nobunori Satoh; Shiro Ueda
Journal:  Pharm World Sci       Date:  2010-08-21

7.  Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.

Authors:  Noam Zelcer; Koen van de Wetering; Michel Hillebrand; Elise Sarton; Annemieke Kuil; Peter R Wielinga; Thomas Tephly; Albert Dahan; Jos H Beijnen; Piet Borst
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-10       Impact factor: 11.205

8.  High levels of morphine-6-glucuronide in street heroin addicts.

Authors:  Letizia Antonilli; Federico Semeraro; Carmen Suriano; Luciano Signore; Paolo Nencini
Journal:  Psychopharmacology (Berl)       Date:  2003-05-28       Impact factor: 4.530

9.  Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration.

Authors:  Scott Edwards; Danielle L Graham; Kimberly N Whisler; David W Self
Journal:  Synapse       Date:  2009-03       Impact factor: 2.562

10.  In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine.

Authors:  Sam Boase; John O Miners
Journal:  Br J Clin Pharmacol       Date:  2002-11       Impact factor: 4.335

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