The effect of selective MAO inhibitors on the conditioned avoidance response of Wistar rats.

Behavioral and biochemical effects of 1-deprenyl and clorgyline were studied in Wistar rats. Behavioral performances was tested in a one-way and in a two-way avoidance system. The two MAO inhibitors were given acutely (1 and 10 mg/kg sc) anc chronically (1 mg/kg sc/daily, for 7 days), and their influences on learning and retention performance was tested 24 hr after the last injection. Behavioral reactions remained unchanged after acute administration of the inhibitors, while they were significantly improved following the chronic treatments, either in the one-way or in the two-way experimental situation. Biochemical analysis indicated dissociation between the influence on striatal dopamine content and the behavioral effects of 1-deprenyl and clorgyline.