Literature DB >> 8874888

Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus.

Y F Lu1, K Tomizawa, A Moriwaki, Y Hayashi, M Tokuda, T Itano, O Hatase, H Matsui.   

Abstract

The effects of FK506, a Ca2+/calmodulin-dependent phosphatase 2B (calcineurin) inhibitor, on the NMDA receptor-mediated potentials and synaptic plasticity were investigated in the CA1 region of the rat hippocampus. Bath application of FK506 (50 microM) produced a 45% inhibition on the NMDA receptor-mediated potentials. FK506 also inhibited the induction of long-term potentiation (LTP), but had no effect on the depotentiation in the CA1 hippocampus. Cyclosporin A (100 microM), another calcineurin inhibitor, mimicked the effects of FK506 on the NMDA responses and synaptic plasticity. These results suggest that FK506 inhibits the activity of NMDA receptors via the involvement of calcineurin. The differential effects of FK506 on LTP and depotentiation may attribute to the partial inhibition on the activity of NMDA receptors and the subsequent attenuation of intracellular Ca2+ increase.

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Year:  1996        PMID： 8874888

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.

Authors:  M Zhuo; W Zhang; H Son; I Mansuy; R A Sobel; J Seidman; E R Kandel
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

2.  Inhibition of calcineurin facilitates the induction of memory for sensitization in Aplysia: requirement of mitogen-activated protein kinase.

Authors:  Shiv K Sharma; Martha W Bagnall; Michael A Sutton; Thomas J Carew
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-02       Impact factor: 11.205

Review 3.  Regulation of neuronal plasticity in the central nervous system by phosphorylation and dephosphorylation.

Authors:  M Tokuda; O Hatase
Journal:  Mol Neurobiol       Date:  1998       Impact factor: 5.590

4.  The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus.

Authors:  A Sík; N Hájos; A Gulácsi; I Mody; T F Freund
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

5.  Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia.

Authors:  Shun-Ming Ting; Xiurong Zhao; Xueping Zheng; Jaroslaw Aronowski
Journal:  J Cereb Blood Flow Metab       Date:  2019-03-19       Impact factor: 6.200

6.  Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

Authors:  Kazuhito Tomizawa; Jun Ohta; Masayuki Matsushita; Akiyoshi Moriwaki; Sheng-Tian Li; Kohji Takei; Hideki Matsui
Journal:  J Neurosci       Date:  2002-04-01       Impact factor: 6.167

7.  Effects Following Intracerebroventricular Injection of Immunosuppressant Cyclosporine A On Inhibitory Avoidance Learning and Memory in Mice.

Authors:  Hamid Reza Banafshe; Mohsen Mohsenpour; Abolfazl Ardjmand
Journal:  Galen Med J       Date:  2018-08-11

8.  Rapamycin Augments the NMDA-Mediated TNF Suppression of MRSA-Stimulated RAW264.7 Murine Macrophages.

Authors:  Thomas Spentzas; Rebekah K H Shappley; Fabio Savorgnan; Elizabeth Meals; B Keith English
Journal:  Int J Inflam       Date:  2012-10-10
  8 in total

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