Literature DB >> 8874150

Human colonic mucosa possesses a mixed population of 5-HT receptors.

R A Borman1, D E Burleigh.   

Abstract

The aim of this study was to characterise the 5-HT receptor(s) mediating secretory responses of isolated human colonic mucosa to 5-HT. Sheets of muscle-stripped mucosa from proximal (ascending) and distal (sigmoid) human colon were set up in Ussing chambers for measurement of short-circuit current (Isc). Serosal application of 5-HT led to non-neural, concentration-dependent increases in Isc. Desensitisation to 5-HT was observed with ascending and sigmoid colonic mucosa. Using selective 5-HT antagonists we have shown that 5-HT induces secretion in sigmoid colon via a 5-HT2A receptor. In ascending colon a combination of 5-HT2A and 5-HT4 receptors appears to be involved.

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Year:  1996        PMID： 8874150     DOI： 10.1016/0014-2999(96)00466-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Authors:  J A M Smith; D T Beattie; D Marquess; J P Shaw; R G Vickery; P P A Humphrey
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-04-16       Impact factor: 3.000

2.  5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle.

Authors:  N H Prins; L M Akkermans; R A Lefebvre; J A Schuurkes
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

3.  5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro.

Authors:  R A Borman; N S Tilford; D W Harmer; N Day; E S Ellis; R L G Sheldrick; J Carey; R A Coleman; G S Baxter
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

4.  An Assessment of the Permeation Enhancer, 1-phenyl-piperazine (PPZ), on Paracellular Flux Across Rat Intestinal Mucosae in Ussing Chambers.

Authors:  V A Bzik; D J Brayden
Journal:  Pharm Res       Date:  2016-07-07       Impact factor: 4.200

5.  The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo.

Authors:  D T Beattie; J A M Smith; D Marquess; R G Vickery; S R Armstrong; T Pulido-Rios; J L McCullough; C Sandlund; C Richardson; N Mai; P P A Humphrey
Journal:  Br J Pharmacol       Date:  2004-10-04       Impact factor: 8.739

Review 6.  Serotonin pharmacology in the gastrointestinal tract: a review.

Authors:  D T Beattie; J A M Smith
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-04-09       Impact factor: 3.000

7.  Predominant mucosal expression of 5-HT₄(+h) receptor splice variants in pig stomach and colon.

Authors:  Evelien K V Priem; Joris H De Maeyer; Mado Vandewoestyne; Dieter Deforce; Romain A Lefebvre
Journal:  World J Gastroenterol       Date:  2013-06-28       Impact factor: 5.742

8.  Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon.

Authors:  Nor S Yaakob; Kenneth A Chinkwo; Navinisha Chetty; Ian M Coupar; Helen R Irving
Journal:  J Neurogastroenterol Motil       Date:  2015-07-30       Impact factor: 4.924

Review 9.  Translational neuropharmacology: the use of human isolated gastrointestinal tissues.

Authors:  G J Sanger; J Broad; V Kung; C H Knowles
Journal:  Br J Pharmacol       Date:  2013-01       Impact factor: 8.739

10.  Human 5-HT(4) and 5-HT(7) receptor splice variants: are they important?

Authors:  Ian M Coupar; Paul V Desmond; Helen R Irving
Journal:  Curr Neuropharmacol       Date:  2007-12       Impact factor: 7.363
  10 in total

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