| Literature DB >> 8873395 |
I Claassen1, J Meylis, P van der Ley, C Peeters, H Brons, J Robert, D Borsboom, A van der Ark, I van Straaten, P Roholl, B Kuipers, J Poolman.
Abstract
An experimental serogroup B meningococcal vaccine was prepared from two genetically engineered strains; each expressing three different class 1 outer membrane proteins (OMPs) (PorA). The two strains expressed the subtypes P1.7,16;P1.5,2;P1.19,15 and P1.5c,10;P1.12,13;P1.7h,4, respectively. Outer membrane vesicles (OMV) were prepared from these strains by deoxycholate extraction, mixed with aluminiumphosphate as adjuvant and formulated to final vaccines. The class 1 OMPs represent ca 90% of the protein in the vaccine. The vaccine was found safe for human use and induced a bactericidal immune response in mice against five of the six wild type strains, which served as donors for the various por A genes.Entities:
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Year: 1996 PMID： 8873395 DOI： 10.1016/0264-410x(96)00020-5
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641