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Literature DB >> 8871403

p70 S6 kinase: an enigma with variations.

Abstract

The S6 ribosomal protein is phosphorylated by p70 S6 kinase (p70S6k). Although the cellular role of S6 phosphorylation is still not fully clear, studies on p70S6k and its activation have revealed the existence of a novel signalling pathway, clues to the mechanism of action of certain immunosuppressants and insights into the control of gene expression at the levels of transcription and translation.

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Year: 1996 PMID： 8871403

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

37 in total

1. Effects of bis(maltolato) oxovanadium (IV) on protein serine kinases in skeletal muscle of streptozotocin-diabetic rats.

Authors: S Bhanot; J Girn; P Poucheret; J H McNeill
Journal: Mol Cell Biochem Date: 1999-12 Impact factor: 3.396

2. Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity.

Authors: N Altiok; S Altiok; J P Changeux
Journal: EMBO J Date: 1997-02-17 Impact factor: 11.598

3. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts.

Authors: N Takuwa; Y Fukui; Y Takuwa
Journal: Mol Cell Biol Date: 1999-02 Impact factor: 4.272

4. Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts.

Authors: S Goruppi; E Ruaro; B Varnum; C Schneider
Journal: Mol Cell Biol Date: 1997-08 Impact factor: 4.272

10. Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells.

Authors: Jingxia Li; Sujatha Dokka; Liying Wang; Xianglin Shi; Vincent Castranova; Yan Yan; Max Costa; Chuanshu Huang
Journal: Mol Cell Biochem Date: 2004-01 Impact factor: 3.396

p70 S6 kinase: an enigma with variations.

1. Effects of bis(maltolato) oxovanadium (IV) on protein serine kinases in skeletal muscle of streptozotocin-diabetic rats.

2. Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity.

3. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts.

4. Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts.

Review 5. Autophagic proteolysis: control and specificity.

6. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.

7. Cholecystokinin activation of 70-kDa S6 kinase in exocrine pancreas.

8. Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

9. Differential role of hydrogen peroxide in UV-induced signal transduction.

10. Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells.