Renal excretion of end products of protein metabolism in urine of endurance trained subjects during restriction of muscular activity.

The objective of this investigation was to determine the rate of renal excretion of end products of protein metabolism in urine of 20 endurance trained male volunteers aged 23-26 years with an average maximum oxygen uptake of 66 ml.kg-1.min-1 during 364 days of hypokinesia (decreased number of running steps/day). All volunteers were on an average of 10,000 running steps/day prior to their exposure to hypokinesia (HK). All volunteers were randomly assigned to one of the two groups. Ten volunteers were placed continuously under 13.9 km/day (10,000 running steps/day) (control subjects) and ten volunteers were subjected continuously under 2.7 km/day (3,000 walking steps/day) (hypokinetic subjects). During the prehypokinetic period of 60 days and during the hypokinetic period of 364 days urinary excretion of total nitrogen, urea and creatinine were determined. All hypokinetic volunteers displaced significant increases in renal excretion of total nitrogen, urea and creatinine as compared to the control group of volunteers. It is concluded that prolonged restriction of muscle activity induces significant increases in urinary excretion of end products of nitrogen metabolism in endurance trained volunteers.

RCT Entities:   Population Interventions Outcomes