Literature DB >> 8867810

Transcriptional downregulation of stromelysin by tetracycline.

C Jonat1, F Z Chung, V M Baragi.   

Abstract

We investigated the role of tetracycline in the transcriptional regulation of matrix metalloproteinases. Using interleukin-1beta (IL-1) induced stromelysin as a model system, we describe the repression of the endogenous stromelysin RNA accumulation, as well as the transcriptional inhibition of various stromelysin promoter/chloramphenicol-acetyltransferase constructs in transient transfection assays. The inhibition occurred in a dose-dependent fashion, with an IC50 of about 1 microM. Our results suggest that the transcriptional inhibition by tetracycline is not due to a block of activity of the activating protein complex 1 (AP-1) but is mediated by sequences upstream of the AP-1 binding site.

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Year:  1996        PMID： 8867810     DOI： 10.1002/(sici)1097-4644(19960301)60:3<341::aid-jcb6>3.0.co;2-w

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  11 in total

Review 1.  Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature.

Authors:  Michael O Griffin; Eduardo Fricovsky; Guillermo Ceballos; Francisco Villarreal
Journal:  Am J Physiol Cell Physiol       Date:  2010-06-30       Impact factor: 4.249

2.  Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury.

Authors:  Michelle P Bendeck; Michelle Conte; Mingyu Zhang; Nafiseh Nili; Bradley H Strauss; Stephanie M Farwell
Journal:  Am J Pathol       Date:  2002-03       Impact factor: 4.307

3.  Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices.

Authors:  Christopher Franco; Bernard Ho; Diane Mulholland; Guangpei Hou; Muzharul Islam; Katey Donaldson; Michelle Patricia Bendeck
Journal:  Am J Pathol       Date:  2006-05       Impact factor: 4.307

4.  Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.

Authors:  A C Lau; T T Duong; S Ito; G J Wilson; R S M Yeung
Journal:  Clin Exp Immunol       Date:  2009-08       Impact factor: 4.330

5.  A nonantibiotic chemically modified tetracycline (CMT-3) inhibits intimal thickening.

Authors:  Muzharul M Islam; Christopher D Franco; David W Courtman; Michelle P Bendeck
Journal:  Am J Pathol       Date:  2003-10       Impact factor: 4.307

Review 6.  Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action.

Authors:  Michael O Griffin; Guillermo Ceballos; Francisco J Villarreal
Journal:  Pharmacol Res       Date:  2010-10-14       Impact factor: 7.658

7.  Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.

Authors:  Abdelhamid Liacini; Judith Sylvester; Wen Qing Li; Muhammad Zafarullah
Journal:  Arthritis Res Ther       Date:  2005-04-04       Impact factor: 5.156

Review 8.  The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs.

Authors:  Hassan Sarker; Ayman Haimour; Ravneet Toor; Carlos Fernandez-Patron
Journal:  Biomolecules       Date:  2021-04-15

9.  Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia: a molecular docking study exploring possible neuroprotection.

Authors:  Anand Kumar Pandey; Pallab Bhattacharya; Swet Chand Shukla; Sudip Paul; Ranjana Patnaik
Journal:  Neural Regen Res       Date:  2015-04       Impact factor: 6.058

10.  Biotic acts of antibiotics.

Authors:  Rustam I Aminov
Journal:  Front Microbiol       Date:  2013-08-19       Impact factor: 5.640
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