Literature DB >> 8867379

In vitro anticryptosporidial activity of dinitroaniline herbicides.

M J Arrowood1, J R Mead, L Xie, X You.   

Abstract

Despite the evaluation of over 100 antimicrobial drugs, the diarrheal disease cryptosporidiosis has remained refractory to treatment. We report the evaluation of five dinitroaniline herbicides including trifluralin, profluralin, nitralin, pendimethalin, and fluchloralin for anticryptosporidial activity in an in vitro cultivation model of Cryptosporidium parvum. All five compounds exhibited significant anticryptosporidial activities with no corresponding evidence of toxicity. The most active compound was pendimethalin with an IC50 of 0.19 microM while nitralin was the least active with an IC50 of 4.5 microM. These compounds should be evaluated further in an animal model of cryptosporidiosis.

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Year:  1996        PMID： 8867379     DOI： 10.1111/j.1574-6968.1996.tb08056.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  12 in total

1.  Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.

Authors:  A Giacometti; O Cirioni; M S Del Prete; F Barchiesi; G Scalise
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

Review 2.  Cytoskeleton of apicomplexan parasites.

Authors:  Naomi S Morrissette; L David Sibley
Journal:  Microbiol Mol Biol Rev       Date:  2002-03       Impact factor: 11.056

Review 3.  In vitro cultivation of cryptosporidium species.

Authors:  Michael J Arrowood
Journal:  Clin Microbiol Rev       Date:  2002-07       Impact factor: 26.132

4.  SPM1 stabilizes subpellicular microtubules in Toxoplasma gondii.

Authors:  Johnson Q Tran; Catherine Li; Alice Chyan; Lawton Chung; Naomi S Morrissette
Journal:  Eukaryot Cell       Date:  2011-10-21

5.  Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii.

Authors:  Molla M Endeshaw; Catherine Li; Jessica de Leon; Ni Yao; Kirk Latibeaudiere; Kokku Premalatha; Naomi Morrissette; Karl A Werbovetz
Journal:  Bioorg Med Chem Lett       Date:  2010-07-08       Impact factor: 2.823

6.  Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.

Authors:  Christopher Ma; Johnson Tran; Frank Gu; Roxanna Ochoa; Catherine Li; David Sept; Karl Werbovetz; Naomi Morrissette
Journal:  Antimicrob Agents Chemother       Date:  2010-02-09       Impact factor: 5.191

Review 7.  A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.

Authors:  William Checkley; A Clinton White; Devan Jaganath; Michael J Arrowood; Rachel M Chalmers; Xian-Ming Chen; Ronald Fayer; Jeffrey K Griffiths; Richard L Guerrant; Lizbeth Hedstrom; Christopher D Huston; Karen L Kotloff; Gagandeep Kang; Jan R Mead; Mark Miller; William A Petri; Jeffrey W Priest; David S Roos; Boris Striepen; R C Andrew Thompson; Honorine D Ward; Wesley A Van Voorhis; Lihua Xiao; Guan Zhu; Eric R Houpt
Journal:  Lancet Infect Dis       Date:  2014-09-29       Impact factor: 25.071

8.  Oral immunization with attenuated Salmonella enterica serovar Typhimurium encoding Cryptosporidium parvum Cp23 and Cp40 antigens induces a specific immune response in mice.

Authors:  Alvaro J Benitez; Nina McNair; Jan R Mead
Journal:  Clin Vaccine Immunol       Date:  2009-07-15

9.  Gene transfer in the evolution of parasite nucleotide biosynthesis.

Authors:  Boris Striepen; Andrea J P Pruijssers; Jinling Huang; Catherine Li; Marc-Jan Gubbels; Nwakaso N Umejiego; Lizbeth Hedstrom; Jessica C Kissinger
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-18       Impact factor: 11.205

10.  Investigation of the reactivity indices for the formation of substituted dinitroanilines and correlations to their dockings on α-tubulin of Plasmodium falciparum.

Authors:  Inemesit A Udofia; Taofeek B Ogunbayo; Oluwakemi A Oloba-Whenu; Chukwuemeka Isanbor; Ponnadurai Ramasami
Journal:  J Mol Model       Date:  2019-11-12       Impact factor: 1.810
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