| Literature DB >> 8866833 |
Abstract
Rifabutin, a rifamycin derivative like rifampicin, has been registered for the treatment of pulmonary tuberculosis and for the prophylaxis and treatment of MAC in patients with AIDS. Rifabutin induces cytochrome P-450 3A4. The effect of rifabutin on the pharmacokinetics and metabolism of drugs administered concomitantly to humans (isoniazid, ethambutol, zidovudine, didanosine, delavirdine, fluconazole, itraconazole, methadone, clarithromycin, theophylline and cyclosporin) has been reviewed.Entities:
Mesh:
Substances:
Year: 1995 PMID: 8866833 DOI: 10.1016/s1043-6618(05)80021-0
Source DB: PubMed Journal: Pharmacol Res ISSN: 1043-6618 Impact factor: 7.658