PURPOSE: To study the potential of buccal delivery of the peptide drug in pigs. METHODS: Intravenous administration and buccal delivery without and with 10 mM sodium glycodeoxycholate (GDC) as absorption enhancer were investigated as a randomised cross-over study in six pigs. The buccal delivery device consisted of an application chamber with a solution of buserelin and was attached to the buccal mucosa for 4 hours using an adhesive patch. RESULTS: Buccal administration of buserelin resulted in rapidly reached steady state plasma levels. The absolute bioavailability of the peptide after buccal delivery for 4 hours could be increased from 1.0 +/- 0.3 to 5.3 +/- 1.1% (mean +/- SD.) by co-administration of 10 mM GDC (0.45% w/v)). CONCLUSIONS: The results of this study demonstrate that buccal administration with the use of absorption enhancers is a useful approach for the delivery of peptide drugs such as buserelin.
PURPOSE: To study the potential of buccal delivery of the peptide drug in pigs. METHODS: Intravenous administration and buccal delivery without and with 10 mM sodium glycodeoxycholate (GDC) as absorption enhancer were investigated as a randomised cross-over study in six pigs. The buccal delivery device consisted of an application chamber with a solution of buserelin and was attached to the buccal mucosa for 4 hours using an adhesive patch. RESULTS: Buccal administration of buserelin resulted in rapidly reached steady state plasma levels. The absolute bioavailability of the peptide after buccal delivery for 4 hours could be increased from 1.0 +/- 0.3 to 5.3 +/- 1.1% (mean +/- SD.) by co-administration of 10 mM GDC (0.45% w/v)). CONCLUSIONS: The results of this study demonstrate that buccal administration with the use of absorption enhancers is a useful approach for the delivery of peptide drugs such as buserelin.
Authors: A J Hoogstraate; J C Verhoef; B Tuk; A Pijpers; L A van Leengoed; J H Verheijden; H E Junginger; H E Boddé Journal: J Pharm Sci Date: 1996-05 Impact factor: 3.534
Authors: A Pijpers; E N Noordhuizen-Stassen; S A Goedegebuure; O A van Dobbenburgh; M Roosendaal; A H Cornelissen; J H Verheijden Journal: Vet Q Date: 1989-10 Impact factor: 3.320
Authors: J B van Bree; A G de Boer; M Danhof; J C Verhoef; T B van Wimersma Greidanus; D D Breimer Journal: Peptides Date: 1988 May-Jun Impact factor: 3.750
Authors: Anne Steimer; Michael Laue; Helmut Franke; Eleonore Haltner-Ukomado; Claus-Michael Lehr Journal: Pharm Res Date: 2006-08-09 Impact factor: 4.200