BACKGROUND: No systemic review of skin reactions to alimentary tract medications is available in the literature. OBJECTIVE: We reviewed the reactions to alimentary tract medications reported to the surveillance system of the Italian Group for Epidemiologic Research in Dermatology (GISED). METHODS: Between January 1988 and December 1994, 202 dermatologists in Italy reported to the coordinating center for GISED all the adverse reactions they observed during prespecified 2-month monitoring periods. Reactions classified under ATC codes A02-A04, A06, A07 and A09 were used for this analysis. RESULTS: Of 2,789 reactions, 48 were attributed to alimentary tract medications. Urticaria/angioedema and exanthemas accounted for about 70% of these reactions. Fixed eruptions and lichenoid dermatitis accounted for a large part of the remaining reactions. Antiulcers and antiemetics appeared remarkably safe. CONCLUSION: Our data are reassuring with regard to the cutaneous reaction profile of several drugs taken for diseases of the alimentary tract.
BACKGROUND: No systemic review of skin reactions to alimentary tract medications is available in the literature. OBJECTIVE: We reviewed the reactions to alimentary tract medications reported to the surveillance system of the Italian Group for Epidemiologic Research in Dermatology (GISED). METHODS: Between January 1988 and December 1994, 202 dermatologists in Italy reported to the coordinating center for GISED all the adverse reactions they observed during prespecified 2-month monitoring periods. Reactions classified under ATC codes A02-A04, A06, A07 and A09 were used for this analysis. RESULTS: Of 2,789 reactions, 48 were attributed to alimentary tract medications. Urticaria/angioedema and exanthemas accounted for about 70% of these reactions. Fixed eruptions and lichenoid dermatitis accounted for a large part of the remaining reactions. Antiulcers and antiemetics appeared remarkably safe. CONCLUSION: Our data are reassuring with regard to the cutaneous reaction profile of several drugs taken for diseases of the alimentary tract.
Authors: L Naldi; A Conforti; M Venegoni; M G Troncon; A Caputi; E Ghiotto; A Cocci; U Moretti; G Velo; R Leone Journal: Br J Clin Pharmacol Date: 1999-12 Impact factor: 4.335