Literature DB >> 8864517

Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo.

L C Stanfa1, V Chapman, N Kerr, A H Dickenson.   

Abstract

Intrathecally administered nociceptin (5, 50, 225 micrograms) dose-relatedly inhibited the C-fibre evoked wind-up and post-discharge of dorsal horn neurones, but not the baseline C-fibre evoked responses. Spinal naloxone 50 micrograms, but not 10 micrograms, reversed the effects of nociceptin. Thus the antinociceptive role of nociceptin in the spinal cord differs from that of classical opioids.

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Year:  1996        PMID： 8864517      PMCID： PMC1909884          DOI： 10.1111/j.1476-5381.1996.tb15618.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

Review 1.  Mechanisms of the analgesic actions of opiates and opioids.

Authors:  A H Dickenson
Journal:  Br Med Bull       Date:  1991-07       Impact factor: 4.291

2.  The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line.

Authors:  M Connor; A Yeo; G Henderson
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739

3.  Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors.

Authors:  M J Wick; S R Minnerath; X Lin; R Elde; P Y Law; H H Loh
Journal:  Brain Res Mol Brain Res       Date:  1994-11

4.  Identification of dynorphins as endogenous ligands for an opioid receptor-like orphan receptor.

Authors:  S Zhang; L Yu
Journal:  J Biol Chem       Date:  1995-09-29       Impact factor: 5.157

5.  Electrophysiologic analysis of preemptive effects of spinal opioids on N-methyl-D-aspartate receptor-mediated events.

Authors:  V Chapman; J E Haley; A H Dickenson
Journal:  Anesthesiology       Date:  1994-12       Impact factor: 7.892

6.  Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones.

Authors:  C W Vaughan; M J Christie
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739

7.  Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.

Authors:  J C Meunier; C Mollereau; L Toll; C Suaudeau; C Moisand; P Alvinerie; J L Butour; J C Guillemot; P Ferrara; B Monsarrat
Journal:  Nature       Date:  1995-10-12       Impact factor: 49.962

8.  Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

Authors:  R K Reinscheid; H P Nothacker; A Bourson; A Ardati; R A Henningsen; J R Bunzow; D K Grandy; H Langen; F J Monsma; O Civelli
Journal:  Science       Date:  1995-11-03       Impact factor: 47.728
  8 in total
  8 in total

1.  Identification of the G-protein-coupled ORL1 receptor in the mouse spinal cord by [35S]-GTPgammaS binding and immunohistochemistry.

Authors:  M Narita; H Mizoguchi; D E Oji; N J Dun; B H Hwang; H Nagase; L F Tseng
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

2.  Mechanical stimulation activates small fiber mediated nociceptive responses in the nucleus gigantocellularis.

Authors:  Tomonari Nagata; Hidehiro Suzuki; Rihui Zhang; Makoto Ozaki; Yoriko Kawakami
Journal:  Exp Brain Res       Date:  2003-03-04       Impact factor: 1.972

3.  Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism.

Authors:  K M Small; S Nag; S S Mokha
Journal:  Neuroscience       Date:  2013-10-24       Impact factor: 3.590

Review 4.  Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists.

Authors:  W Schröder; D G Lambert; M C Ko; T Koch
Journal:  Br J Pharmacol       Date:  2014-08       Impact factor: 8.739

Review 5.  Pharmacology of nociceptin and its receptor: a novel therapeutic target.

Authors:  G Calo'; R Guerrini; A Rizzi; S Salvadori; D Regoli
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

Review 6.  Central N/OFQ-NOP Receptor System in Pain Modulation.

Authors:  Norikazu Kiguchi; Huiping Ding; Mei-Chuan Ko
Journal:  Adv Pharmacol       Date:  2015-12-17

Review 7.  Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.

Authors:  Lawrence Toll; Michael R Bruchas; Girolamo Calo'; Brian M Cox; Nurulain T Zaveri
Journal:  Pharmacol Rev       Date:  2016-03-08       Impact factor: 25.468

8.  Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat.

Authors:  Jomo A Claiborne; Subodh Nag; Sukhbir S Mokha
Journal:  Neurosci Lett       Date:  2009-04-05       Impact factor: 3.046
  8 in total

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