Literature DB >> 8864516

EndothelinB (ETB) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus.

L B Fernandes1, P J Henry, P J Rigby, R G Goldie.   

Abstract

In human isolated bronchial preparations, the endothelinB (ETB) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n = 9). This effect was blocked in the presence of the ETB receptor-selective antagonist, BQ-788 (10 microM). These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.

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Year:  1996        PMID： 8864516      PMCID： PMC1909875          DOI： 10.1111/j.1476-5381.1996.tb15617.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

Review 1.  Endothelin and the respiratory system.

Authors:  D W Hay; P J Henry; R G Goldie
Journal:  Trends Pharmacol Sci       Date:  1993-01       Impact factor: 14.819

2.  Inhibition by endothelin-1 of cholinergic nerve-mediated acetylcholine release and contraction in sheep isolated trachea.

Authors:  P J Henry; A Shen; F Mitchelson; R G Goldie
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

3.  Relationship between endothelin-1 binding site densities and constrictor activities in human and animal airway smooth muscle.

Authors:  P J Henry; P J Rigby; G J Self; J M Preuss; R G Goldie
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

4.  Endothelin immunoreactivity of airway epithelium in asthmatic patients.

Authors:  D R Springall; P H Howarth; H Counihan; R Djukanovic; S T Holgate; J M Polak
Journal:  Lancet       Date:  1991-03-23       Impact factor: 79.321

5.  Endothelin-3 increases transmission in the rabbit pulmonary parasympathetic nervous system.

Authors:  K O McKay; C L Armour; J L Black
Journal:  J Cardiovasc Pharmacol       Date:  1993       Impact factor: 3.105

6.  Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways.

Authors:  R G Goldie; P J Henry; P G Knott; G J Self; M A Luttmann; D W Hay
Journal:  Am J Respir Crit Care Med       Date:  1995-11       Impact factor: 21.405

7.  Potentiation by endothelin-1 of cholinergic nerve-mediated contractions in mouse trachea via activation of ETB receptors.

Authors:  P J Henry; R G Goldie
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

8.  Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi.

Authors:  J L Ellis; B J Undem
Journal:  Am J Respir Crit Care Med       Date:  1994-01       Impact factor: 21.405
  8 in total
  5 in total

1.  Pharmacological characterization of endothelin receptor subtypes in the guinea-pig prostate gland.

Authors:  W A Lau; S L Cox; J N Pennefather; F J Mitchelson
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

2.  Characterization of endothelin receptors in the peripheral lung tissues of horses unaffected and affected with recurrent airway obstruction.

Authors:  Sumanth Polikepahad; Masudul Haque; Joseph Francis; Rustin M Moore; Changaram S Venugopal
Journal:  Can J Vet Res       Date:  2008-07       Impact factor: 1.310

3.  Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.

Authors:  B D'Agostino; C Advenier; M Falciani; L Gallelli; G Marrocco; E Piegari; A Filippelli; F Rossi
Journal:  Br J Pharmacol       Date:  2001-12       Impact factor: 8.739

4.  Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation.

Authors:  P Raval; S Bingham; N Aiyar; J D Elliott; A J Hunter; E H Ohlstein; A A Parsons
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

5.  Modulation of ET-1-induced contraction of human bronchi by airway epithelium-dependent nitric oxide release via ET(A) receptor activation.

Authors:  E Naline; C Bertrand; K Biyah; Y Fujitani; T Okada; A Bisson; C Advenier
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739
  5 in total

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