| Literature DB >> 8864494 |
T Fukuda1, K Watabe, J Tanaka.
Abstract
The effects of bromocriptine and/or L-DOPA on substantia nigra neurons of MPTP-intoxicated mice were investigated. L-DOPA reduced the number of neurons. Bromocriptine protected the neurons from damage by L-DOPA but had no effect on the neurons damaged by MPTP. The treatment of bromocriptine and L-DOPA protected the neurons compared with single administration of bromocriptine. It seems reasonable to suppose that bromocriptine should be added to L-DOPA in order to protect the neurons in parkinsonism.Entities:
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Year: 1996 PMID： 8864494 DOI： 10.1016/0006-8993(96)00559-8
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252