Literature DB >> 886444

Determination of dextrorphan in plasma and evaluation of bioavailability of dextromethorphan hydrobromide in humans.

G Ramachander, F D Williams, J F Emele.   

Abstract

A method is described for the estimation of dextrorphan, a metabolite of dextromethorphan, in plasma. The bioavailability of dextromethorphan hydrobromide after 30 mg po, as measured by the concentration of total (free and conjugated) dextrorphan in the plasma, was determined in six human volunteers with this procedure.

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Year:  1977        PMID： 886444     DOI： 10.1002/jps.2600660740

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  7 in total

1.  Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004.

Authors:  Jodi K Bryner; Uerica K Wang; Jenny W Hui; Merilin Bedodo; Conan MacDougall; Ilene B Anderson
Journal:  Arch Pediatr Adolesc Med       Date:  2006-12

2.  Oxidative polymorphism of dextromethorphan in a Burundi population.

Authors:  F Nsabiyumva; Y Furet; E Autret; A P Jonville; M Breteau
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

3.  The effect of inhaled and oral dextromethorphan on citric acid induced cough in man.

Authors:  T J Grattan; A E Marshall; K S Higgins; A H Morice
Journal:  Br J Clin Pharmacol       Date:  1995-03       Impact factor: 4.335

4.  Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver.

Authors:  F Broly; C Libersa; M Lhermitte; P Bechtel; B Dupuis
Journal:  Br J Clin Pharmacol       Date:  1989-07       Impact factor: 4.335

5.  Randomized open-label trial of dextromethorphan in Rett syndrome.

Authors:  Constance L Smith-Hicks; Siddharth Gupta; Joshua B Ewen; Manisha Hong; Lisa Kratz; Richard Kelley; Elaine Tierney; Rebecca Vaurio; Genila Bibat; Abanti Sanyal; Gayane Yenokyan; Nga Brereton; Michael V Johnston; Sakkubai Naidu
Journal:  Neurology       Date:  2017-09-20       Impact factor: 9.910

6.  Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice.

Authors:  Pao-Pao Yang; Geng-Chang Yeh; Eagle Yi-Kung Huang; Ping-Yee Law; Horace H Loh; Pao-Luh Tao
Journal:  J Biomed Sci       Date:  2015-09-22       Impact factor: 8.410

7.  Signs & symptoms of Dextromethorphan exposure from YouTube.

Authors:  Michael Chary; Emily H Park; Andrew McKenzie; Julia Sun; Alex F Manini; Nicholas Genes
Journal:  PLoS One       Date:  2014-02-12       Impact factor: 3.240
  7 in total

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