Literature DB >> 8864236

Novel antiplatelet constituents from formosan moraceous plants.

C N Lin1, C M Lu, H C Lin, S C Fang, B J Shieh, M F Hsu, J P Wang, F N Ko, C M Teng.   

Abstract

Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 microM). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.

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Year:  1996        PMID： 8864236     DOI： 10.1021/np960376j

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

1.  Cytotoxic effect of artocarpin on T47D cells.

Authors:  Enos Tangke Arung; Britanto Dani Wicaksono; Yohana Ayupriyanti Handoko; Irawan Wijaya Kusuma; Kuniyoshi Shimizu; Dina Yulia; Ferry Sandra
Journal:  J Nat Med       Date:  2010-06-11       Impact factor: 2.343

2.  Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood.

Authors:  Ibrahim Jantan; Yusyila H Mohd Yasin; Shajarahtunnur Jamil; Hasnah Sirat; Norazah Basar
Journal:  J Nat Med       Date:  2010-03-27       Impact factor: 2.343

3.  Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils.

Authors:  Jih-Pyang Wang; Mei-Feng Hsu; Horng-Huey Ko; Chun-Nan Lin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-11-19       Impact factor: 3.000

4.  Inhibitory Effects of Cycloheterophyllin on Melanin Synthesis.

Authors:  Joong-Hyun Shim
Journal:  Molecules       Date:  2021-04-26       Impact factor: 4.411

5.  12-Acetyl-6-hy-droxy-3,3,9,9-tetra-methyl-furo[3,4-b]pyrano[3,2-h]xanthene-7,11(3H,9H)-dione.

Authors:  Gwendoline Cheng Lian Ee; Siow Hwa Teo; Huey Chong Kwong; Mohamed Ibrahim Mohamed Tahir; Sidik Silong
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-27

6.  1-Methyl-3-(2-methyl-phen-yl)-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c][1,2]oxazole-3a-carbonitrile.

Authors:  K Swaminathan; K Sethusankar; G Murugan; M Bakthadoss
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-03-19

7.  Chemical composition and antioxidant activities of Broussonetia papyrifera fruits.

Authors:  Jie Sun; Shao-fang Liu; Chu-shu Zhang; Li-na Yu; Jie Bi; Feng Zhu; Qing-li Yang
Journal:  PLoS One       Date:  2012-02-28       Impact factor: 3.240

8.  Methyl 3-(4-isopropyl-phen-yl)-1-phenyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carboxyl-ate.

Authors:  J Kanchanadevi; G Anbalagan; J Srinivasan; M Bakthadoss; V Manivannan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-07-09

9.  Photoprotective Effects of Cycloheterophyllin against UVA-Induced Damage and Oxidative Stress in Human Dermal Fibroblasts.

Authors:  Cheng-Hua Huang; Hsin-Ju Li; Nan-Lin Wu; Chien-Yu Hsiao; Chun-Nan Lin; Hsun-Hsien Chang; Chi-Feng Hung
Journal:  PLoS One       Date:  2016-09-01       Impact factor: 3.240

10.  Methyl 6-eth-oxy-3-phenyl-3a,4-dihydro-3H-chromeno[4,3-c]isoxazole-3a-car-boxylate.

Authors:  G Suresh; J Srinivasan; M Bakthadoss; S Aravindhan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-01-04
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