| Literature DB >> 8863990 |
H Schellekens1, H Niphuis, L Buijs, P Douw van der Krap, H K Hochkeppel, J L Heeney.
Abstract
The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.Entities:
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Year: 1996 PMID： 8863990 DOI： 10.1016/0166-3542(95)00955-8
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970