Pathohistology of undecalcified primary teeth in vitamin D-resistant rickets: review and report of two cases.

The basic dental defects in vitamin D-resistant rickets seem to be manifested in dentin. Enamel is usually reported to be normal. This histologic examination showed the penetration of microorganisms through the calcified structures of the enamel layer without visible caries. The microorganisms passed through the dentinoenamel junction and invaded dentin, which was characterized by calcospherites and large amounts of interglobular dentin. Furthermore, microorganisms could be detected in dentinal tubules, which were exposed to the oral cavity when enamel was removed. However, large areas of tertiary dentin extended between such tubules and the pulp. These light microscopic results suggest that clinical manifestations, such as, pulp recrosis and periapical lesions (without carious defects) may be caused by the penetration of microorganisms through microclefts of the enamel layer as well as pathologically altered enamel microstructures of affected teeth.