Literature DB >> 8862763

The influence of aging on renal response to cadmium in Syrian hamsters.

T Shibasaki1, Q Y Xu, I Ohno, F Ishimoto, O Sakai.   

Abstract

To determine the renal effects of cadmium (Cd) in older animals, we administered subcutaneously a single dose of cadmium, 3.0 mg/kg/BW, to Syrian hamsters aged 16 wk ("young") and 60 wk ("old"). Marked morphologic changes in the kidney and renal dysfunction were observed, especially in the older animals. The concentration of MDA in the renal cortex was significantly increased only in young hamsters treated with cadmium. Concentrations of glutathione (GSH) in the renal cortex were increased in the old hamsters on d 6. Increased levels of renal MDA after cadmium treatment may induce the production of GSH in the kidney thus preventing renal damage. Aging can increase the susceptibility to the renal effects of cadmium.

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Year:  1996        PMID： 8862763     DOI： 10.1007/BF02785322

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  16 in total

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Authors:  M M Jones; M G Cherian
Journal:  Toxicology       Date:  1990-05-14       Impact factor: 4.221

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Authors:  S Rehm; M P Waalkes
Journal:  Toxicol Appl Pharmacol       Date:  1990-06-01       Impact factor: 4.219

10.  Characteristics of cadmium-induced nephrotoxicity in Syrian hamsters.

Authors:  T Shibasaki; I Ohno; F Ishimoto; O Sakai
Journal:  Nihon Jinzo Gakkai Shi       Date:  1993-08
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  2 in total

1.  Effects of a hepato-protective agent and a hepato-secreting chelator on cadmium-induced nephrotoxicity in Syrian hamsters.

Authors:  T Shibasaki; H Matsumoto; H Gomi; I Ohno; F Ishimoto; O Sakai
Journal:  Biol Trace Elem Res       Date:  1996-04       Impact factor: 3.738

2.  The late and persistent pathogenic effects of cadmium at very low levels on the kidney of rats.

Authors:  Bo Wang; Qi Luo; Chen Shao; Xin Li; Feng Li; Yanan Liu; Liankun Sun; Yang Li; Lu Cai
Journal:  Dose Response       Date:  2011-12-02       Impact factor: 2.658
  2 in total

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