Literature DB >> 8862549

Prediction of the three-dimensional structure of human interleukin-7 by homology modeling.

R T Kroemer1, S W Doughty, A J Robinson, W G Richards.   

Abstract

The three-dimensional structure of human interleukin (IL)-7 has been predicted based on homology to human IL-2, IL-4, granulocyte-macrophage colony stimulating factor and growth hormone. The model has a topology common to other cytokines and displays a unique disulfide pattern. Knowledge of the tertiary structure of IL-7 has implications for analysis of key binding regions, suggestions for mutagenesis experiments and design of (ant)agonists. In this context, the model is discussed and compared with other cytokine structures.

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Year:  1996        PMID： 8862549     DOI： 10.1093/protein/9.6.493

Source DB:  PubMed          Journal:  Protein Eng        ISSN： 0269-2139


  13 in total

1.  Enzymatic properties of newly found green turtle egg white ribonuclease.

Authors:  Somporn Katekaew; Takao Torikata; Hideki Hirakawa; Satoru Kuhara; Tomohiro Araki
Journal:  Protein J       Date:  2007-02       Impact factor: 2.371

2.  Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations.

Authors:  Nidhi Singh; Mitchell A Avery; Christopher R McCurdy
Journal:  J Comput Aided Mol Des       Date:  2007-09-14       Impact factor: 3.686

3.  Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.

Authors:  Rafael Andrade Caceres; Luís Fernando Saraiva Macedo Timmers; Ana Luiza Vivan; Cristopher Zandoná Schneider; Luiz Augusto Basso; Walter Filgueira De Azevedo; Diogenes Santiago Santos
Journal:  J Mol Model       Date:  2008-03-15       Impact factor: 1.810

4.  Structural analysis and molecular dynamics simulations of novel δ-endotoxin Cry1Id from Bacillus thuringiensis to pave the way for development of novel fusion proteins against insect pests of crops.

Authors:  Budheswar Dehury; Mousumi Sahu; Jagajjit Sahu; Kishore Sarma; Priyabrata Sen; Mahendra K Modi; Madhumita Barooah; Manabendra Dutta Choudhury
Journal:  J Mol Model       Date:  2013-10-24       Impact factor: 1.810

5.  ATP4A gene regulatory network for fine-tuning of proton pump and ion channels.

Authors:  Vijai Singh; Indra Mani; Dharmendra Kumar Chaudhary
Journal:  Syst Synth Biol       Date:  2013-01-09

6.  Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation.

Authors:  L Cosenza; A Rosenbach; J V White; J R Murphy; T Smith
Journal:  Protein Sci       Date:  2000-05       Impact factor: 6.725

7.  Molecular modeling and dynamics studies of purine nucleoside phosphorylase from Bacteroides fragilis.

Authors:  Ivani Pauli; Luis Fernando Saraiva Macedo Timmers; Rafael Andrade Caceres; Luiz Augusto Basso; Diógenes Santiago Santos; Walter Filgueira de Azevedo
Journal:  J Mol Model       Date:  2009-01-27       Impact factor: 1.810

8.  Exploring CYP1A1 as anticancer target: homology modeling and in silico inhibitor design.

Authors:  Abhay T Sangamwar; Leena B Labhsetwar; Sharad V Kuberkar
Journal:  J Mol Model       Date:  2008-07-30       Impact factor: 1.810

9.  Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP.

Authors:  Guy Barros Barcellos; Rafael Andrade Caceres; Walter Filgueira de Azevedo
Journal:  J Mol Model       Date:  2008-11-29       Impact factor: 1.810

10.  Crystallization and preliminary X-ray diffraction of human interleukin-7 bound to unglycosylated and glycosylated forms of its alpha-receptor.

Authors:  Joseph Wickham; Scott T R Walsh
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-09-19
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