Literature DB >> 8862464

Prenatal hypoxia alters the postnatal development of beta-adrenoceptors in the rat myocardium.

J Roigas1, C Roigas, D Heydeck, B Papies.   

Abstract

The effect of prenatal hypoxia on the development of the beta-adrenoceptor during the ontogenesis of rats was investigated. It was shown that the offspring from hypoxic dams, in comparison with normoxic control animals, exhibited alterations of the density (Bmax) of the myocardial beta-receptors and of the catecholamine levels in heart tissue during development. The results suggest that the beta-adrenoceptor changes might be involved in the phenomenon of enhanced sensitivity of prenatal hypoxic animals to catecholamines in adult age.

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Year:  1996        PMID： 8862464     DOI： 10.1159/000244335

Source DB:  PubMed          Journal:  Biol Neonate        ISSN： 0006-3126


  8 in total

1.  Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts.

Authors:  Andrew J Patterson; Man Chen; Qin Xue; Daliao Xiao; Lubo Zhang
Journal:  Circ Res       Date:  2010-06-10       Impact factor: 17.367

Review 2.  Epigenetic mechanisms in developmental programming of adult disease.

Authors:  Man Chen; Lubo Zhang
Journal:  Drug Discov Today       Date:  2011-09-16       Impact factor: 7.851

3.  Foetal hypoxia increases cardiac AT(2)R expression and subsequent vulnerability to adult ischaemic injury.

Authors:  Qin Xue; Chiranjib Dasgupta; Man Chen; Lubo Zhang
Journal:  Cardiovasc Res       Date:  2010-09-23       Impact factor: 10.787

4.  The effect of fetal hypoxia on adrenocortical function in the 7-day-old rat.

Authors:  H Raff; E D Bruder; B M Jankowski; W C Engeland
Journal:  Endocrine       Date:  2000-08       Impact factor: 3.633

5.  Developmental programming resulting from maternal obesity in mice: effects on myocardial ischaemia-reperfusion injury.

Authors:  John W Calvert; David J Lefer; Susheel Gundewar; Lucilla Poston; William A Coetzee
Journal:  Exp Physiol       Date:  2009-04-24       Impact factor: 2.969

Review 6.  The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo.

Authors:  N Itani; C E Salinas; M Villena; K L Skeffington; C Beck; E Villamor; C E Blanco; D A Giussani
Journal:  J Physiol       Date:  2017-11-15       Impact factor: 5.182

7.  Prenatal hypoxia-induced epigenomic and transcriptomic reprogramming in rat fetal and adult offspring hearts.

Authors:  Xin Chen; Lubo Zhang; Charles Wang
Journal:  Sci Data       Date:  2019-10-29       Impact factor: 6.444

8.  Multi-Omics Integration Reveals Short and Long-Term Effects of Gestational Hypoxia on the Heart Development.

Authors:  Yu Gao; Chiranjib Dasgupta; Lei Huang; Rui Song; Ziwei Zhang; Lubo Zhang
Journal:  Cells       Date:  2019-12-11       Impact factor: 6.600
  8 in total

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