Literature DB >> 8862012

Absence of correlation between chemo- and radioresistance in a range of human tumour cell lines.

M Heenan1, K Kavanagh, A Redmond, M Maher, E Dolan, P O'Neill, M Moriarty, M Clynes.   

Abstract

The correlation between cellular resistance to radiation and to chemotherapeutic drugs has been investigated in a number of solid tumour cell lines, and preliminary results indicate no direct relationship. The acquisition of a multidrug resistance (MDR) profile by adriamycin-selected variants of a human squamous lung carcinoma, an ovarian carcinoma, a cervical carcinoma and by a colchicine-selected variant of a Chinese hamster ovarian carcinoma resulted in alterations to their radiosensitivity. However, the degree of change in the radiosensitivity of the MDR cell lines could not be predicted from their level of resistance to adriamycin. Clonal populations derived from DLKP-A, an adriamycin-selected MDR variant of the human lung carcinoma cell line DLKP, exhibited individual radiosensitivity profiles, which did not correlate with their chemoresistance. Exposure of DLKP to consecutive increasing doses of radiation did not confer cross-resistance to chemotherapeutic drugs.

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Year:  1996        PMID: 8862012     DOI: 10.1007/bf00744218

Source DB:  PubMed          Journal:  Cytotechnology        ISSN: 0920-9069            Impact factor:   2.058


  14 in total

1.  Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas.

Authors:  C A Quiet; R R Weichselbaum; D J Grdina
Journal:  Int J Radiat Oncol Biol Phys       Date:  1991-04       Impact factor: 7.038

2.  Differences in radiation response between cells in S-phase and non-S-phase cells of the granulocyte/macrophage progenitor (GM-CFC) compartment.

Authors:  W Nothdurft; K Baltschukat; C Selig
Journal:  Int J Radiat Oncol Biol Phys       Date:  1992       Impact factor: 7.038

3.  Cytogenetic comparison of two poorly differentiated human lung squamous cell carcinoma lines.

Authors:  E Law; U Gilvarry; V Lynch; B Gregory; G Grant; M Clynes
Journal:  Cancer Genet Cytogenet       Date:  1992-04

4.  Overexpression of P-glycoprotein in human lung carcinoma xenografts after fractionated irradiation in vivo.

Authors:  J Mattern; T Efferth; M Volm
Journal:  Radiat Res       Date:  1991-09       Impact factor: 2.841

5.  Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant.

Authors:  G E Iliakis; R Okayasu
Journal:  Int J Radiat Biol       Date:  1990-06       Impact factor: 2.694

6.  Chinese hamster pleiotropic multidrug-resistant cells are not radioresistant.

Authors:  J B Mitchell; J Gamson; A Russo; N Friedman; W DeGraff; J Carmichael; E Glatstein
Journal:  NCI Monogr       Date:  1988

7.  Comparison of 5 microplate colorimetric assays for in vitro cytotoxicity testing and cell proliferation assays.

Authors:  A Martin; M Clynes
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

8.  Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs.

Authors:  M J Allalunis-Turner; G M Barron; R S Day; K D Dobler; R Mirzayans
Journal:  Radiat Res       Date:  1993-06       Impact factor: 2.841

Review 9.  Human cell lines as models for multidrug resistance in solid tumours.

Authors:  M Clynes; M Heenan; K Hall
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

10.  Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A.

Authors:  M Clynes; A Redmond; E Moran; U Gilvarry
Journal:  Cytotechnology       Date:  1992       Impact factor: 2.058

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  1 in total

1.  Radiation- and chemoinduced multidrug resistance in colon carcinoma cells.

Authors:  Detlef Bartkowiak; Michael Stempfhuber; Thomas Wiegel; Dirk Bottke
Journal:  Strahlenther Onkol       Date:  2009-12       Impact factor: 3.621

  1 in total

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