Literature DB >> 8861907

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.

F B Gertler1, K Niebuhr, M Reinhard, J Wehland, P Soriano.   

Abstract

Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila AbI. We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain targets Mena to localized proteins containing a specific proline-rich motif. The association of Mena with the surface of the intracellular pathogen Listeria monocytogenes and the G-actin binding protein profilin suggests that this molecule may participate in bacterial movement by facilitating actin polymerization. Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility.

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Year:  1996        PMID： 8861907     DOI： 10.1016/s0092-8674(00)81341-0

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  208 in total

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10.  Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties.

Authors:  A Lambrechts; A Braun; V Jonckheere; A Aszodi; L M Lanier; J Robbens; I Van Colen; J Vandekerckhove; R Fässler; C Ampe
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