Literature DB >> 8861618

Localisation of NADPH diaphorase activity and NOS immunoreactivity in astroglia in normal adult rat brain.

P L Gabbott1, S J Bacon.   

Abstract

This study demonstrates the co-localisation of NADPH diaphorase activity and GFAP immunoreactivity in non-neuronal cells in weakly fixed brain sections from normal adult rats. The presence of GFAP immunoreactivity in these cells indicates that they are astroglia. In addition, cells possessing the morphological characteristics of astroglia were weakly immunoreactive for the endothelial isoform of nitric oxide synthase (eNOS)--these cells also co-localised NADPH diaphorase activity. Furthermore, cells immunoreactive for eNOS displayed GFAP immunoreactive processes. This cytochemical evidence strongly suggests that resting astroglia are potential sources of nitric oxide--a powerful modulator of cell activity.

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Year:  1996        PMID： 8861618     DOI： 10.1016/0006-8993(95)01509-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

1.  Induction of NO synthase and glial acidic fibrillary protein in astrocytes in the temporal cortex of the rat with audiogenic epileptiform reactions.

Authors:  S G Kalinichenko; Yu V Dudina; I V Dyuizen; P A Motavkin
Journal:  Neurosci Behav Physiol       Date:  2005-07

2.  Contribution of central nervous system endothelial nitric oxide synthase to neurohumoral activation in heart failure rats.

Authors:  Vinicia C Biancardi; Sook J Son; Patrick M Sonner; Hong Zheng; Kaushik P Patel; Javier E Stern
Journal:  Hypertension       Date:  2011-08-08       Impact factor: 10.190

3.  Cellular sources, targets and actions of constitutive nitric oxide in the magnocellular neurosecretory system of the rat.

Authors:  Javier E Stern; Wenfeng Zhang
Journal:  J Physiol       Date:  2004-11-18       Impact factor: 5.182

Review 4.  The Interplay between cGMP and Calcium Signaling in Alzheimer's Disease.

Authors:  Aileen Jehle; Olga Garaschuk
Journal:  Int J Mol Sci       Date:  2022-06-24       Impact factor: 6.208

5.  Identification and localization of cell types that express endothelial and neuronal nitric oxide synthase in the rat nucleus tractus solitarii.

Authors:  L H Lin; O Taktakishvili; W T Talman
Journal:  Brain Res       Date:  2007-08-08       Impact factor: 3.252

6.  Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation.

Authors:  Xiaohui Zhang; Rohini Polavarapu; Hua She; Zixu Mao; Manuel Yepes
Journal:  Am J Pathol       Date:  2007-08-23       Impact factor: 4.307

Review 7.  Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca(2+) signaling.

Authors:  Manuel F Muñoz; Mariela Puebla; Xavier F Figueroa
Journal:  Front Cell Neurosci       Date:  2015-03-10       Impact factor: 5.505

8.  Methylmercury Neurotoxicity: Exploring Potential Novel Targets.

Authors:  J L Aschner; M Aschner
Journal:  Open Toxicol J       Date:  2007-10-17

Review 9.  The role of astrocytes in oxidative stress of central nervous system: A mixed blessing.

Authors:  Yaxing Chen; Chen Qin; Jianhan Huang; Xin Tang; Chang Liu; Keru Huang; Jianguo Xu; Gang Guo; Aiping Tong; Liangxue Zhou
Journal:  Cell Prolif       Date:  2020-02-08       Impact factor: 6.831

10.  Endothelial nitric oxide synthase regulates white matter changes via the BDNF/TrkB pathway after stroke in mice.

Authors:  Xu Cui; Michael Chopp; Alex Zacharek; Ruizhuo Ning; Xiaoshuang Ding; Cynthia Roberts; Jieli Chen
Journal:  PLoS One       Date:  2013-11-13       Impact factor: 3.240
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