OBJECTIVE: The objective of this study was to determine the efficacy of low-dose estrogens, administered locally, in postmenopausal women with symptoms and signs of atrophic vaginitis. Transvaginal ultrasonography was performed for the evaluation of endometrial or ovarian abnormalities. MATERIALS AND METHODS: Fifty-six healthy postmenopausal women with symptoms of atrophic vaginitis due to estrogen deficiency were examined with transvaginal ultrasound. The endometrial thickness, the uterus and the ovaries were measured before and after 6 months of treatment with low-dose estrogens. RESULTS: The mean endometrial thickness, before and after treatment was 3.1 +/- 0.8 mm and 3.1 +/- 1.2 mm respectively. The mean ovarian volume before treatment was 4.5 ml and there was no difference after treatment. There were no changes in uterine thickness during the treatment period. CONCLUSIONS: Our study, using transvaginal ultrasonography, has shown that low-dose estrogens, administered locally, give no sign of endometrial proliferation, measured as endometrial thickness, and do not alter the ovarian volume in postmenopausal volume.
OBJECTIVE: The objective of this study was to determine the efficacy of low-dose estrogens, administered locally, in postmenopausal women with symptoms and signs of atrophic vaginitis. Transvaginal ultrasonography was performed for the evaluation of endometrial or ovarian abnormalities. MATERIALS AND METHODS: Fifty-six healthy postmenopausal women with symptoms of atrophic vaginitis due to estrogen deficiency were examined with transvaginal ultrasound. The endometrial thickness, the uterus and the ovaries were measured before and after 6 months of treatment with low-dose estrogens. RESULTS: The mean endometrial thickness, before and after treatment was 3.1 +/- 0.8 mm and 3.1 +/- 1.2 mm respectively. The mean ovarian volume before treatment was 4.5 ml and there was no difference after treatment. There were no changes in uterine thickness during the treatment period. CONCLUSIONS: Our study, using transvaginal ultrasonography, has shown that low-dose estrogens, administered locally, give no sign of endometrial proliferation, measured as endometrial thickness, and do not alter the ovarian volume in postmenopausal volume.