Long-term effects of retinal lesions on growth-associated protein 43 (GAP-43) expression in the visual system of adult cats.

We have investigated the role of growth-associated protein 43 (GAP-43) in synaptic reorganization in the visual system of adult cats that received binocular central retinal lesions. Different survival times between 3 and 8 months after induction of the lesion were chosen. In the deafferented part of the dorsal lateral geniculate nucleus (dLGN) we found a long-lasting increase in GAP-43 protein, while glial fibrillary acidic protein (GFAP) immunoreactivity, which initially increased due to the degeneration of retinal ganglion cells, slowly subsided over this period. In area 17, the pattern of GAP-43 expression did not provide indications for morphological changes in the cortical architecture following retinal lesions.