Literature DB >> 8858311

Dual effects of endothelin-1 on the L-type Ca2+ current in ventricular cardiomyocytes.

E Kelso1, P Spiers, B McDermott, N Scholfield, B Silke.   

Abstract

The effects of endothelin-1 on the L-type Ca2+ current were studied in rabbit ventricular cardiomyocytes, using both the 'perforated' and the conventional 'ruptured' whole-cell patch-clamp techniques. Endothelin-1 exerts a dual effect on ventricular cardiomyocytes using experimental conditions which minimize intracellular dialysis; endothelin-1 produced both an increase (10(-9) M) and a decrease (10(-8) M) in the L-type Ca2+ current using the perforated patch-clamp technique. However, using the ruptured patch-clamp technique, endothelin-1 produced a similar decrease in L-type Ca2+ current at 10(-8) M, but no effect was observed at a concentration of 10(-9) M. These effects suggest multiplicity in the receptor-effector coupling mechanism.

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Year:  1996        PMID： 8858311     DOI： 10.1016/0014-2999(96)00366-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.

Authors:  Mark D Levin; Gautam K Singh; Hai Xia Zhang; Keita Uchida; Beth A Kozel; Phyllis K Stein; Atilla Kovacs; Ruth E Westenbroek; William A Catterall; Dorothy Katherine Grange; Colin G Nichols
Journal:  Proc Natl Acad Sci U S A       Date:  2016-05-31       Impact factor: 11.205

2.  Endothelin-1 Decreases Excitability of the Dorsal Root Ganglion Neurons via ETB Receptor.

Authors:  Nandkishor K Mule; Jitendra N Singh; Kunal U Shah; Anil Gulati; Shyam S Sharma
Journal:  Mol Neurobiol       Date:  2017-06-16       Impact factor: 5.590

3.  Endothelin-1 and photoreleased diacylglycerol increase L-type Ca2+ current by activation of protein kinase C in rat ventricular myocytes.

Authors:  J Q He; Y Pi; J W Walker; T J Kamp
Journal:  J Physiol       Date:  2000-05-01       Impact factor: 5.182

4.  Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.

Authors:  José L Puglisi; Weilong Yuan; Valeriy Timofeyev; Richard E Myers; Nipavan Chiamvimonvat; Allen M Samarel; Donald M Bers
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-12-03       Impact factor: 4.733

5.  Muscle on a chip: in vitro contractility assays for smooth and striated muscle.

Authors:  Anna Grosberg; Alexander P Nesmith; Josue A Goss; Mark D Brigham; Megan L McCain; Kevin Kit Parker
Journal:  J Pharmacol Toxicol Methods       Date:  2012-04-12       Impact factor: 1.950

6.  Negative inotropic effects of endothelin-1 in mouse cardiomyocytes: evidence of a role for Na+-Ca2+ exchange.

Authors:  A F James
Journal:  Br J Pharmacol       Date:  2007-08-27       Impact factor: 8.739

7.  Protein phosphatase 1 and an opposing protein kinase regulate steady-state L-type Ca2+ current in mouse cardiac myocytes.

Authors:  William H duBell; Terry B Rogers
Journal:  J Physiol       Date:  2004-01-23       Impact factor: 5.182
  7 in total

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