| Literature DB >> 8858284 |
M F Duggan-Keen1, P J Keating, F R Stevens, P Sinnott, P J Snijders, J M Walboomers, S Davidson, R D Hunter, P A Dyer, P L Stern.
Abstract
No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.Entities:
Mesh：
Year: 1996 PMID： 8858284 DOI： 10.1111/j.1744-313x.1996.tb00123.x
Source DB: PubMed Journal: Eur J Immunogenet ISSN： 0960-7420