| Literature DB >> 8856973 |
R I Morimoto1, P E Kroeger, J J Cotto.
Abstract
The inducible regulation of heat shock gene transcription is mediated by a family of heat shock factors (HSF) that respond to diverse forms of physiological and environmental stress including elevated temperature, amino acid analogs, heavy metals, oxidative stress, anti-inflammatory drugs, arachidonic acid, and a number of pathophysiological disease states. The vertebrate genome encodes a family of HSFs which are expressed ubiquitously, yet the DNA binding properties of each factor are negatively regulated and activated in response to specific conditions. This chapter will discuss the regulation of the HSF multi-gene family and the role of these transcriptional activators in the inducible expression of genes encoding heat shock proteins and molecular chaperones.Entities:
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Year: 1996 PMID： 8856973 DOI： 10.1007/978-3-0348-9088-5_10
Source DB: PubMed Journal: EXS ISSN： 1023-294X